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Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort
BACKGROUND: The autonomic nervous system plays a key role in maintaining homeostasis and responding to external stimuli. In adults, exposure to fine particulate matter ([Formula: see text]) has been associated with reduced heart rate variability (HRV), an indicator of cardiac autonomic control. OBJE...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Environmental Health Perspectives
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867319/ https://www.ncbi.nlm.nih.gov/pubmed/31663780 http://dx.doi.org/10.1289/EHP4434 |
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author | Cowell, Whitney J. Brunst, Kelly J. Malin, Ashley J. Coull, Brent A. Gennings, Chris Kloog, Itai Lipton, Lianna Wright, Robert O. Enlow, Michelle Bosquet Wright, Rosalind J. |
author_facet | Cowell, Whitney J. Brunst, Kelly J. Malin, Ashley J. Coull, Brent A. Gennings, Chris Kloog, Itai Lipton, Lianna Wright, Robert O. Enlow, Michelle Bosquet Wright, Rosalind J. |
author_sort | Cowell, Whitney J. |
collection | PubMed |
description | BACKGROUND: The autonomic nervous system plays a key role in maintaining homeostasis and responding to external stimuli. In adults, exposure to fine particulate matter ([Formula: see text]) has been associated with reduced heart rate variability (HRV), an indicator of cardiac autonomic control. OBJECTIVES: Our goal was to investigate the associations of exposure to fine particulate matter ([Formula: see text]) with HRV as an indicator of cardiac autonomic control during early development. METHODS: We studied 237 maternal–infant pairs in a Boston-based birth cohort. We estimated daily residential [Formula: see text] using satellite data in combination with land-use regression predictors. In infants at 6 months of age, we measured parasympathetic nervous system (PNS) activity using continuous electrocardiogram monitoring during the Repeated Still-Face Paradigm, an experimental protocol designed to elicit autonomic reactivity in response to maternal interaction and disengagement. We used multivariable linear regression to examine average [Formula: see text] exposure across pregnancy in relation to PNS withdrawal and activation, indexed by changes in respiration-corrected respiratory sinus arrhythmia ([Formula: see text])—an established metric of HRV that reflects cardiac vagal tone. We examined interactions with infant sex using cross-product terms. RESULTS: In adjusted models we found that a 1-unit increase in [Formula: see text] (in micrograms per cubic meter) was associated with a 3.53% decrease in baseline [Formula: see text] (95% CI: [Formula: see text] , 0.02). In models examining [Formula: see text] change between episodes, higher [Formula: see text] was generally associated with reduced PNS withdrawal during stress and reduced PNS activation during recovery; however, these associations were not statistically significant. We did not observe a significant interaction between [Formula: see text] and sex. DISCUSSION: Prenatal exposure to [Formula: see text] may disrupt cardiac vagal tone during infancy. Future research is needed to replicate these preliminary findings. https://doi.org/10.1289/EHP4434 |
format | Online Article Text |
id | pubmed-6867319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Environmental Health Perspectives |
record_format | MEDLINE/PubMed |
spelling | pubmed-68673192019-11-25 Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort Cowell, Whitney J. Brunst, Kelly J. Malin, Ashley J. Coull, Brent A. Gennings, Chris Kloog, Itai Lipton, Lianna Wright, Robert O. Enlow, Michelle Bosquet Wright, Rosalind J. Environ Health Perspect Research BACKGROUND: The autonomic nervous system plays a key role in maintaining homeostasis and responding to external stimuli. In adults, exposure to fine particulate matter ([Formula: see text]) has been associated with reduced heart rate variability (HRV), an indicator of cardiac autonomic control. OBJECTIVES: Our goal was to investigate the associations of exposure to fine particulate matter ([Formula: see text]) with HRV as an indicator of cardiac autonomic control during early development. METHODS: We studied 237 maternal–infant pairs in a Boston-based birth cohort. We estimated daily residential [Formula: see text] using satellite data in combination with land-use regression predictors. In infants at 6 months of age, we measured parasympathetic nervous system (PNS) activity using continuous electrocardiogram monitoring during the Repeated Still-Face Paradigm, an experimental protocol designed to elicit autonomic reactivity in response to maternal interaction and disengagement. We used multivariable linear regression to examine average [Formula: see text] exposure across pregnancy in relation to PNS withdrawal and activation, indexed by changes in respiration-corrected respiratory sinus arrhythmia ([Formula: see text])—an established metric of HRV that reflects cardiac vagal tone. We examined interactions with infant sex using cross-product terms. RESULTS: In adjusted models we found that a 1-unit increase in [Formula: see text] (in micrograms per cubic meter) was associated with a 3.53% decrease in baseline [Formula: see text] (95% CI: [Formula: see text] , 0.02). In models examining [Formula: see text] change between episodes, higher [Formula: see text] was generally associated with reduced PNS withdrawal during stress and reduced PNS activation during recovery; however, these associations were not statistically significant. We did not observe a significant interaction between [Formula: see text] and sex. DISCUSSION: Prenatal exposure to [Formula: see text] may disrupt cardiac vagal tone during infancy. Future research is needed to replicate these preliminary findings. https://doi.org/10.1289/EHP4434 Environmental Health Perspectives 2019-10-30 /pmc/articles/PMC6867319/ /pubmed/31663780 http://dx.doi.org/10.1289/EHP4434 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. |
spellingShingle | Research Cowell, Whitney J. Brunst, Kelly J. Malin, Ashley J. Coull, Brent A. Gennings, Chris Kloog, Itai Lipton, Lianna Wright, Robert O. Enlow, Michelle Bosquet Wright, Rosalind J. Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort |
title | Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort |
title_full | Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort |
title_fullStr | Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort |
title_full_unstemmed | Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort |
title_short | Prenatal Exposure to [Formula: see text] and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort |
title_sort | prenatal exposure to [formula: see text] and cardiac vagal tone during infancy: findings from a multiethnic birth cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867319/ https://www.ncbi.nlm.nih.gov/pubmed/31663780 http://dx.doi.org/10.1289/EHP4434 |
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