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Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives

BACKGROUND: The substitution of bisphenol A (BPA) by bisphenol B (BPB), a very close structural analog, stresses the need to assess its potential endocrine properties. OBJECTIVE: This analysis aimed to investigate whether BPB has endocrine disruptive properties in humans and in wildlife as defined b...

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Autores principales: Serra, Hélène, Beausoleil, Claire, Habert, René, Minier, Christophe, Picard-Hagen, Nicole, Michel, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867436/
https://www.ncbi.nlm.nih.gov/pubmed/31617754
http://dx.doi.org/10.1289/EHP5200
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author Serra, Hélène
Beausoleil, Claire
Habert, René
Minier, Christophe
Picard-Hagen, Nicole
Michel, Cécile
author_facet Serra, Hélène
Beausoleil, Claire
Habert, René
Minier, Christophe
Picard-Hagen, Nicole
Michel, Cécile
author_sort Serra, Hélène
collection PubMed
description BACKGROUND: The substitution of bisphenol A (BPA) by bisphenol B (BPB), a very close structural analog, stresses the need to assess its potential endocrine properties. OBJECTIVE: This analysis aimed to investigate whether BPB has endocrine disruptive properties in humans and in wildlife as defined by the World Health Organization (WHO) definition used in the regulatory field, that is, a) adverse effects, b) endocrine activity, and c) plausible mechanistic links between the observed endocrine activity and adverse effects. METHODS: We conducted a systematic review to identify BPB adverse effects and endocrine activities by focusing on animal models and in vitro mechanistic studies. The results were grouped by modality (estrogenic, androgenic, thyroid hormone, steroidogenesis-related, or other endocrine activities). After critical analysis of results, lines of evidence were built using a weight-of-evidence approach to establish a biologically plausible link. In addition, the ratio of BPA to BPB potency was reported from studies investigating both bisphenols. RESULTS: Among the 36 articles included in the analysis, 3 subchronic studies consistently reported effects of BPB on reproductive function. In rats, the 28-d and 48-week studies showed alteration of spermatogenesis associated with a lower height of the seminiferous tubules, the alteration of several sperm parameters, and a weight loss for the testis, epididymis, and seminal vesicles. In zebrafish, the results of a 21-d reproductive study demonstrated that exposed fish had a lower egg production and a lower hatching rate and viability. The in vitro and in vivo mechanistic data consistently demonstrated BPB’s capacity to decrease testosterone production and to exert an estrogenic-like activity similar to or greater than BPA’s, both pathways being potentially responsible for spermatogenesis impairment in rats and fish. CONCLUSION: The available in vivo, ex vivo, and in vitro data, although limited, coherently indicates that BPB meets the WHO definition of an endocrine disrupting chemical currently used in a regulatory context. https://doi.org/10.1289/EHP5200
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spelling pubmed-68674362019-11-25 Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives Serra, Hélène Beausoleil, Claire Habert, René Minier, Christophe Picard-Hagen, Nicole Michel, Cécile Environ Health Perspect Review BACKGROUND: The substitution of bisphenol A (BPA) by bisphenol B (BPB), a very close structural analog, stresses the need to assess its potential endocrine properties. OBJECTIVE: This analysis aimed to investigate whether BPB has endocrine disruptive properties in humans and in wildlife as defined by the World Health Organization (WHO) definition used in the regulatory field, that is, a) adverse effects, b) endocrine activity, and c) plausible mechanistic links between the observed endocrine activity and adverse effects. METHODS: We conducted a systematic review to identify BPB adverse effects and endocrine activities by focusing on animal models and in vitro mechanistic studies. The results were grouped by modality (estrogenic, androgenic, thyroid hormone, steroidogenesis-related, or other endocrine activities). After critical analysis of results, lines of evidence were built using a weight-of-evidence approach to establish a biologically plausible link. In addition, the ratio of BPA to BPB potency was reported from studies investigating both bisphenols. RESULTS: Among the 36 articles included in the analysis, 3 subchronic studies consistently reported effects of BPB on reproductive function. In rats, the 28-d and 48-week studies showed alteration of spermatogenesis associated with a lower height of the seminiferous tubules, the alteration of several sperm parameters, and a weight loss for the testis, epididymis, and seminal vesicles. In zebrafish, the results of a 21-d reproductive study demonstrated that exposed fish had a lower egg production and a lower hatching rate and viability. The in vitro and in vivo mechanistic data consistently demonstrated BPB’s capacity to decrease testosterone production and to exert an estrogenic-like activity similar to or greater than BPA’s, both pathways being potentially responsible for spermatogenesis impairment in rats and fish. CONCLUSION: The available in vivo, ex vivo, and in vitro data, although limited, coherently indicates that BPB meets the WHO definition of an endocrine disrupting chemical currently used in a regulatory context. https://doi.org/10.1289/EHP5200 Environmental Health Perspectives 2019-10-16 /pmc/articles/PMC6867436/ /pubmed/31617754 http://dx.doi.org/10.1289/EHP5200 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Review
Serra, Hélène
Beausoleil, Claire
Habert, René
Minier, Christophe
Picard-Hagen, Nicole
Michel, Cécile
Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives
title Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives
title_full Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives
title_fullStr Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives
title_full_unstemmed Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives
title_short Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives
title_sort evidence for bisphenol b endocrine properties: scientific and regulatory perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867436/
https://www.ncbi.nlm.nih.gov/pubmed/31617754
http://dx.doi.org/10.1289/EHP5200
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