Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile

Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spontaneously or be facilitated by the glutathione S-tr...

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Detalles Bibliográficos
Autores principales: Behrens, Kelsey A., Jania, Leigh A., Snouwaert, John N., Nguyen, MyTrang, Moy, Sheryl S., Tikunov, Andrey P., Macdonald, Jeffrey M., Koller, Beverly H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867637/
https://www.ncbi.nlm.nih.gov/pubmed/31747445
http://dx.doi.org/10.1371/journal.pone.0225449

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