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The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis

BACKGROUND: Published studies have investigated the prognostic roles of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in gastroesophageal cancer patients with the controversial results. The aim of the study was to systematically evaluate the impacts of ERα and ERβ on the overall sur...

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Autores principales: Zhang, Dongyun, Ku, Jianwei, Yi, Yingjie, Zhang, Junhui, Liu, Rongzhi, Tang, Nianya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867741/
https://www.ncbi.nlm.nih.gov/pubmed/31725654
http://dx.doi.org/10.1097/MD.0000000000017954
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author Zhang, Dongyun
Ku, Jianwei
Yi, Yingjie
Zhang, Junhui
Liu, Rongzhi
Tang, Nianya
author_facet Zhang, Dongyun
Ku, Jianwei
Yi, Yingjie
Zhang, Junhui
Liu, Rongzhi
Tang, Nianya
author_sort Zhang, Dongyun
collection PubMed
description BACKGROUND: Published studies have investigated the prognostic roles of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in gastroesophageal cancer patients with the controversial results. The aim of the study was to systematically evaluate the impacts of ERα and ERβ on the overall survival (OS) in patients. METHOD: Relevant eligible studies were extracted from PubMed, Embase, Web of Science, CNKI and Wanfang databases (from the start date to November 2018) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. HR (hazard ratio) with 95% confidence intervals (CIs) were used to assess the prognostic values of ERα and ERβ for OS in patients. RESULTS: High ERα expression was associated with poor OS (HR = 1.58, 95% CI = 1.29–1.94, P < .001) and ERβ with better OS (HR = 0.56, 95% CI = 0.37–0.83, P = .004) in gastroesophageal cancer. Furthermore, unfavorable OS was found in Chinese gastroesophageal patients with higher ERα expression (HR = 1.57, 95% CI = 1.25–1.96, P < .001) and better OS with higher ERβ expression (HR = 0.51, 95% CI = 0.31–0.83, P < .01) in our subgroup analysis. Meanwhile, worse OS was found in esophageal squamous cell carcinoma (ESCC) patients with high ERα expression (HR = 1.74, 95% CI = 1.33–2.26, P < .001), and favorable OS in ESCC with ERβ overexpression (HR = 0.40, 95% CI = 0.31–0.52, P < .001). Besides, high ERα expression was associated with lower tumor differentiation in ESCC (OR = 1.64; 95% CI = 1.02–2.64, P = .04) and ERβ was linked with better tumor differentiation in gastric adenocarcinoma (GCA) (OR = 0.49; 95% CI = 0.26–0.94, P = .03). CONCLUSIONS: ERα and ERβ might serve as potential prognostic biomarkers for gastroesophageal cancer patients. ERα overexpression predicted poor OS and lower tumor differentiation, and ERβ suggested favorable OS and better tumor differentiation. Further related studies should be performed to test these results.
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spelling pubmed-68677412020-01-14 The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis Zhang, Dongyun Ku, Jianwei Yi, Yingjie Zhang, Junhui Liu, Rongzhi Tang, Nianya Medicine (Baltimore) 4500 BACKGROUND: Published studies have investigated the prognostic roles of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in gastroesophageal cancer patients with the controversial results. The aim of the study was to systematically evaluate the impacts of ERα and ERβ on the overall survival (OS) in patients. METHOD: Relevant eligible studies were extracted from PubMed, Embase, Web of Science, CNKI and Wanfang databases (from the start date to November 2018) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. HR (hazard ratio) with 95% confidence intervals (CIs) were used to assess the prognostic values of ERα and ERβ for OS in patients. RESULTS: High ERα expression was associated with poor OS (HR = 1.58, 95% CI = 1.29–1.94, P < .001) and ERβ with better OS (HR = 0.56, 95% CI = 0.37–0.83, P = .004) in gastroesophageal cancer. Furthermore, unfavorable OS was found in Chinese gastroesophageal patients with higher ERα expression (HR = 1.57, 95% CI = 1.25–1.96, P < .001) and better OS with higher ERβ expression (HR = 0.51, 95% CI = 0.31–0.83, P < .01) in our subgroup analysis. Meanwhile, worse OS was found in esophageal squamous cell carcinoma (ESCC) patients with high ERα expression (HR = 1.74, 95% CI = 1.33–2.26, P < .001), and favorable OS in ESCC with ERβ overexpression (HR = 0.40, 95% CI = 0.31–0.52, P < .001). Besides, high ERα expression was associated with lower tumor differentiation in ESCC (OR = 1.64; 95% CI = 1.02–2.64, P = .04) and ERβ was linked with better tumor differentiation in gastric adenocarcinoma (GCA) (OR = 0.49; 95% CI = 0.26–0.94, P = .03). CONCLUSIONS: ERα and ERβ might serve as potential prognostic biomarkers for gastroesophageal cancer patients. ERα overexpression predicted poor OS and lower tumor differentiation, and ERβ suggested favorable OS and better tumor differentiation. Further related studies should be performed to test these results. Wolters Kluwer Health 2019-11-15 /pmc/articles/PMC6867741/ /pubmed/31725654 http://dx.doi.org/10.1097/MD.0000000000017954 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4500
Zhang, Dongyun
Ku, Jianwei
Yi, Yingjie
Zhang, Junhui
Liu, Rongzhi
Tang, Nianya
The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis
title The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis
title_full The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis
title_fullStr The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis
title_full_unstemmed The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis
title_short The prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: A meta-analysis
title_sort prognostic values of estrogen receptor alpha and beta in patients with gastroesophageal cancer: a meta-analysis
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867741/
https://www.ncbi.nlm.nih.gov/pubmed/31725654
http://dx.doi.org/10.1097/MD.0000000000017954
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