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Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM

OBJECTIVE: The primary aim of this study is to examine the hemodynamics of retrobulbar and intrarenal in the changes of early stage of type 2 diabetes mellitus (T2DM) patients from 2000 to 2015 and to assess incidence associated with diabetic kidney disease (DKD) and diabetic retinopathy (DR). METHO...

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Autores principales: Tai, He, Jiang, Xiao-lin, Kuang, Jin-song, Yang, Yu-feng, Song, Nan, Yu, JJ JiaJia, Cui, Yong, Du, Ying, Wu, Yao, Zhang, Han-wen, Cui, Xin-yue, Li, Na, Zhang, Li-de, Fu, Xin, Jia, Lian-qun, Yang, Guan-lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867759/
https://www.ncbi.nlm.nih.gov/pubmed/31725621
http://dx.doi.org/10.1097/MD.0000000000017792
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author Tai, He
Jiang, Xiao-lin
Kuang, Jin-song
Yang, Yu-feng
Song, Nan
Yu, JJ JiaJia
Cui, Yong
Du, Ying
Wu, Yao
Zhang, Han-wen
Cui, Xin-yue
Li, Na
Zhang, Li-de
Fu, Xin
Jia, Lian-qun
Yang, Guan-lin
author_facet Tai, He
Jiang, Xiao-lin
Kuang, Jin-song
Yang, Yu-feng
Song, Nan
Yu, JJ JiaJia
Cui, Yong
Du, Ying
Wu, Yao
Zhang, Han-wen
Cui, Xin-yue
Li, Na
Zhang, Li-de
Fu, Xin
Jia, Lian-qun
Yang, Guan-lin
author_sort Tai, He
collection PubMed
description OBJECTIVE: The primary aim of this study is to examine the hemodynamics of retrobulbar and intrarenal in the changes of early stage of type 2 diabetes mellitus (T2DM) patients from 2000 to 2015 and to assess incidence associated with diabetic kidney disease (DKD) and diabetic retinopathy (DR). METHOD: Our study contained 60 subjects newly diagnosed of T2DM were divided into 2 groups base on the mean resistive index (RI) (≤0.7 and >0.7) of hemodynamic and to compare between-group differences of the early changes in hemodynamics of retrobulbar and intrarenal and also to conclude the incidences of diabetic kidney disease (DKD) and diabetic retinopathy (DR)subsequently with a long follow-up duration(2000–2015). First, to compare the mean RI of central retinal artery (CRA) between 2 groups. Second, to compare the mean RI of intrarenal hemodynamics in the bilateral interlobular renal arteries, renal function parameters (blood urea nitrogen (BUN), creatinine (Cr), blood glucose parameters (glycosylated hemoglobinA1c (HbA1c), fasting plasma glucose (FBG), and 2-hour postprandial blood glucose (2hPBG)), glomerular filtration rate (GFR), albumin excretion rate (AER), and urine albumin-to-creatinine ratio (UACR) between 2 groups. RESULTS: First part of our follow-up studies was to compare hemodynamic RI index of retrobulbar in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs ≤0.7. Incidence of DKD and DR was notably lower in group RIs ≤0.7 than group RIs > 0.7, difference was statistically significant (P < .05). Incidence of HbA1c ≤7% was higher in group RIs ≤0.7 than group RIs >0.7, but difference was not statistically significant (P > .05). Incidence of proliferative diabetic retinopathy (PDR) was notably lower in group RIs ≤0.7 than group RIs >0.7, but the difference was not statistically significant (P > .05). Second part of our follow-up studies was to compare hemodynamic RI index of interlobular renal in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs ≤0.7. Compared data of various incidences from first part of study were coherent with second part. (Incidence of DKD and DR was notably lower in group RIs ≤0.7 than group RIs >0.7, difference was statistically significant (P < .05). Incidence of HbA1c ≤7% was higher in group RIs ≤0.7 than group RIs >0.7, but difference was not statistically significant (P > .05). Incidence of PDR was notably lower in group RIs ≤0.7 than group RIs >0.7, but the difference was not statistically significant (P > .05). CONCLUSIONS: RIs of retrobulbar and interlobular renal which would serve as a good predictors for the hemodynamics changes in retrobulbar and intrarenal would assess incidence of DKD and DR during the preclinical stage in long-term range excluding renal function and HbA1c in T2DM patients.
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spelling pubmed-68677592020-01-14 Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM Tai, He Jiang, Xiao-lin Kuang, Jin-song Yang, Yu-feng Song, Nan Yu, JJ JiaJia Cui, Yong Du, Ying Wu, Yao Zhang, Han-wen Cui, Xin-yue Li, Na Zhang, Li-de Fu, Xin Jia, Lian-qun Yang, Guan-lin Medicine (Baltimore) 3700 OBJECTIVE: The primary aim of this study is to examine the hemodynamics of retrobulbar and intrarenal in the changes of early stage of type 2 diabetes mellitus (T2DM) patients from 2000 to 2015 and to assess incidence associated with diabetic kidney disease (DKD) and diabetic retinopathy (DR). METHOD: Our study contained 60 subjects newly diagnosed of T2DM were divided into 2 groups base on the mean resistive index (RI) (≤0.7 and >0.7) of hemodynamic and to compare between-group differences of the early changes in hemodynamics of retrobulbar and intrarenal and also to conclude the incidences of diabetic kidney disease (DKD) and diabetic retinopathy (DR)subsequently with a long follow-up duration(2000–2015). First, to compare the mean RI of central retinal artery (CRA) between 2 groups. Second, to compare the mean RI of intrarenal hemodynamics in the bilateral interlobular renal arteries, renal function parameters (blood urea nitrogen (BUN), creatinine (Cr), blood glucose parameters (glycosylated hemoglobinA1c (HbA1c), fasting plasma glucose (FBG), and 2-hour postprandial blood glucose (2hPBG)), glomerular filtration rate (GFR), albumin excretion rate (AER), and urine albumin-to-creatinine ratio (UACR) between 2 groups. RESULTS: First part of our follow-up studies was to compare hemodynamic RI index of retrobulbar in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs ≤0.7. Incidence of DKD and DR was notably lower in group RIs ≤0.7 than group RIs > 0.7, difference was statistically significant (P < .05). Incidence of HbA1c ≤7% was higher in group RIs ≤0.7 than group RIs >0.7, but difference was not statistically significant (P > .05). Incidence of proliferative diabetic retinopathy (PDR) was notably lower in group RIs ≤0.7 than group RIs >0.7, but the difference was not statistically significant (P > .05). Second part of our follow-up studies was to compare hemodynamic RI index of interlobular renal in years of 2000 and 2015, both renal function and blood glucose parameters were fund significantly enhanced in subject group RIs ≤0.7. Compared data of various incidences from first part of study were coherent with second part. (Incidence of DKD and DR was notably lower in group RIs ≤0.7 than group RIs >0.7, difference was statistically significant (P < .05). Incidence of HbA1c ≤7% was higher in group RIs ≤0.7 than group RIs >0.7, but difference was not statistically significant (P > .05). Incidence of PDR was notably lower in group RIs ≤0.7 than group RIs >0.7, but the difference was not statistically significant (P > .05). CONCLUSIONS: RIs of retrobulbar and interlobular renal which would serve as a good predictors for the hemodynamics changes in retrobulbar and intrarenal would assess incidence of DKD and DR during the preclinical stage in long-term range excluding renal function and HbA1c in T2DM patients. Wolters Kluwer Health 2019-11-15 /pmc/articles/PMC6867759/ /pubmed/31725621 http://dx.doi.org/10.1097/MD.0000000000017792 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3700
Tai, He
Jiang, Xiao-lin
Kuang, Jin-song
Yang, Yu-feng
Song, Nan
Yu, JJ JiaJia
Cui, Yong
Du, Ying
Wu, Yao
Zhang, Han-wen
Cui, Xin-yue
Li, Na
Zhang, Li-de
Fu, Xin
Jia, Lian-qun
Yang, Guan-lin
Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM
title Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM
title_full Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM
title_fullStr Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM
title_full_unstemmed Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM
title_short Longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with T2DM
title_sort longitudinal follow-up study of the retrobulbar and intrarenal hemodynamics in patients with t2dm
topic 3700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867759/
https://www.ncbi.nlm.nih.gov/pubmed/31725621
http://dx.doi.org/10.1097/MD.0000000000017792
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