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Selection on mutators is not frequency-dependent

The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent. Mutators can invade a population by hitchhiking with a sweeping beneficial mutation, but motivated by earlier e...

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Detalles Bibliográficos
Autores principales: Raynes, Yevgeniy, Weinreich, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867826/
https://www.ncbi.nlm.nih.gov/pubmed/31697233
http://dx.doi.org/10.7554/eLife.51177
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author Raynes, Yevgeniy
Weinreich, Daniel
author_facet Raynes, Yevgeniy
Weinreich, Daniel
author_sort Raynes, Yevgeniy
collection PubMed
description The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent. Mutators can invade a population by hitchhiking with a sweeping beneficial mutation, but motivated by earlier experiments results, it has been repeatedly suggested that mutators must be sufficiently frequent to produce such a driver mutation before non-mutators do. Here, we use stochastic, agent-based simulations to show that neither the strength nor the sign of selection on mutators depend on their initial frequency, and while the overall probability of hitchhiking increases predictably with frequency, the per-capita probability of fixation remains unchanged.
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spelling pubmed-68678262019-11-25 Selection on mutators is not frequency-dependent Raynes, Yevgeniy Weinreich, Daniel eLife Evolutionary Biology The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent. Mutators can invade a population by hitchhiking with a sweeping beneficial mutation, but motivated by earlier experiments results, it has been repeatedly suggested that mutators must be sufficiently frequent to produce such a driver mutation before non-mutators do. Here, we use stochastic, agent-based simulations to show that neither the strength nor the sign of selection on mutators depend on their initial frequency, and while the overall probability of hitchhiking increases predictably with frequency, the per-capita probability of fixation remains unchanged. eLife Sciences Publications, Ltd 2019-11-07 /pmc/articles/PMC6867826/ /pubmed/31697233 http://dx.doi.org/10.7554/eLife.51177 Text en © 2019, Raynes and Weinreich https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Raynes, Yevgeniy
Weinreich, Daniel
Selection on mutators is not frequency-dependent
title Selection on mutators is not frequency-dependent
title_full Selection on mutators is not frequency-dependent
title_fullStr Selection on mutators is not frequency-dependent
title_full_unstemmed Selection on mutators is not frequency-dependent
title_short Selection on mutators is not frequency-dependent
title_sort selection on mutators is not frequency-dependent
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867826/
https://www.ncbi.nlm.nih.gov/pubmed/31697233
http://dx.doi.org/10.7554/eLife.51177
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