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Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization

Antibodies are essential for immunity against Ehrlichia chaffeensis, and protective mechanisms involve blocking of ehrlichial attachment or complement and Fcγ-receptor-dependent destruction. In this study, we determined that major outer membrane protein 1 (OMP-19) hypervariable region 1 (HVR1)-speci...

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Detalles Bibliográficos
Autores principales:	Velayutham, Thangam Sudha, Kumar, Sandeep, Zhang, Xiaofeng, Kose, Nurgun, Walker, David H., Winslow, Gary, Crowe, James E., McBride, Jere W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Microbial Immunity and Vaccines
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867850/ https://www.ncbi.nlm.nih.gov/pubmed/31548319 http://dx.doi.org/10.1128/IAI.00383-19

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