Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2

Although intrinsically disordered protein regions (IDPRs) are commonly engaged in promiscuous protein-protein interactions (PPIs), using them as drug targets is challenging due to their extreme structural flexibility. We report a rational discovery of inhibitors targeting an IDPR of MBD2 that underg...

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Detalles Bibliográficos
Autores principales: Kim, Min Young, Na, Insung, Kim, Ji Sook, Son, Seung Han, Choi, Sungwoo, Lee, Seol Eui, Kim, Ji-Hun, Jang, Kiseok, Alterovitz, Gil, Chen, Yu, van der Vaart, Arjan, Won, Hyung-Sik, Uversky, Vladimir N., Kim, Chul Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867884/
https://www.ncbi.nlm.nih.gov/pubmed/31799386
http://dx.doi.org/10.1126/sciadv.aav9810

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