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A sperm peptide enhances long-term memory in female Drosophila

Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer...

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Autores principales: Scheunemann, L., Lampin-Saint-Amaux, A., Schor, J., Preat, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867886/
https://www.ncbi.nlm.nih.gov/pubmed/31799390
http://dx.doi.org/10.1126/sciadv.aax3432
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author Scheunemann, L.
Lampin-Saint-Amaux, A.
Schor, J.
Preat, T.
author_facet Scheunemann, L.
Lampin-Saint-Amaux, A.
Schor, J.
Preat, T.
author_sort Scheunemann, L.
collection PubMed
description Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. A peptide in the male sperm, the sex peptide, is known to cause marked changes in female reproductive behavior, as well as other behaviors such as dietary preference. Here, we demonstrate that this sex peptide enhances memory by acting on a single pair of serotonergic brain neurons, in which activation of the sex peptide receptor stimulates the cyclic adenosine monophosphate/protein kinase A pathway. We thus reveal a strong effect of mating on memory via the neuromodulatory action of a sperm peptide on the female brain.
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spelling pubmed-68678862019-12-03 A sperm peptide enhances long-term memory in female Drosophila Scheunemann, L. Lampin-Saint-Amaux, A. Schor, J. Preat, T. Sci Adv Research Articles Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. A peptide in the male sperm, the sex peptide, is known to cause marked changes in female reproductive behavior, as well as other behaviors such as dietary preference. Here, we demonstrate that this sex peptide enhances memory by acting on a single pair of serotonergic brain neurons, in which activation of the sex peptide receptor stimulates the cyclic adenosine monophosphate/protein kinase A pathway. We thus reveal a strong effect of mating on memory via the neuromodulatory action of a sperm peptide on the female brain. American Association for the Advancement of Science 2019-11-20 /pmc/articles/PMC6867886/ /pubmed/31799390 http://dx.doi.org/10.1126/sciadv.aax3432 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Scheunemann, L.
Lampin-Saint-Amaux, A.
Schor, J.
Preat, T.
A sperm peptide enhances long-term memory in female Drosophila
title A sperm peptide enhances long-term memory in female Drosophila
title_full A sperm peptide enhances long-term memory in female Drosophila
title_fullStr A sperm peptide enhances long-term memory in female Drosophila
title_full_unstemmed A sperm peptide enhances long-term memory in female Drosophila
title_short A sperm peptide enhances long-term memory in female Drosophila
title_sort sperm peptide enhances long-term memory in female drosophila
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867886/
https://www.ncbi.nlm.nih.gov/pubmed/31799390
http://dx.doi.org/10.1126/sciadv.aax3432
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