A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions

To understand the evolution of Verona integron-encoded metallo-β-lactamase (VIM) genes (bla(VIM)) and their clinical impact, microbiological, biochemical, and structural studies were conducted. Forty-five clinically derived VIM variants engineered in a uniform background and expressed in Escherichia...

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Detalles Bibliográficos
Autores principales: Cheng, Zishuo, Shurina, Ben A., Bethel, Christopher R., Thomas, Pei W., Marshall, Steven H., Thomas, Caitlyn A., Yang, Kundi, Kimble, Robert L., Montgomery, Jonathan S., Orischak, Matthew G., Miller, Callie M., Tennenbaum, Jordan L., Nix, Jay C., Tierney, David L., Fast, Walter, Bonomo, Robert A., Page, Richard C., Crowder, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867895/
https://www.ncbi.nlm.nih.gov/pubmed/31744917
http://dx.doi.org/10.1128/mBio.02412-19

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