Discovery of novel potential selective HDAC8 inhibitors by combine ligand-based, structure-based virtual screening and in-vitro biological evaluation

Neuroblastoma is the most common extracranial solid tumor found in children and survival rate is extremely meager. HDAC8, a class I zinc-dependent enzyme, is a potential drug target for treatment of neuroblastoma and T cell lymphoma. Most of the HDAC8 inhibitors discovered till date contains a hydro...

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Detalles Bibliográficos
Autores principales: Debnath, Sudhan, Debnath, Tanusree, Bhaumik, Samhita, Majumdar, Swapan, Kalle, Arunasree M., Aparna, Vema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868012/
https://www.ncbi.nlm.nih.gov/pubmed/31748509
http://dx.doi.org/10.1038/s41598-019-53376-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868012/
https://www.ncbi.nlm.nih.gov/pubmed/31748509
http://dx.doi.org/10.1038/s41598-019-53376-y

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