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Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation

Telomere maintenance is critical for chromosome stability. Here we report that periodic tryptophan protein 1 (PWP1) is involved in regulating telomere length homeostasis. Pwp1 appears to be essential for mouse development and embryonic stem cell (ESC) survival, as homozygous Pwp1-knockout mice and E...

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Detalles Bibliográficos
Autores principales:	Yu, Yangyang, Jia, Wenwen, Lyu, Yao, Su, Dingwen, Bai, Mingliang, Shen, Junwei, Qiao, Jing, Han, Tong, Liu, Wenqiang, Chen, Jiayu, Chen, Wen, Ye, Dan, Guo, Xudong, Zhu, Songcheng, Xi, Jiajie, Zhu, Ruixin, Wan, Xiaoping, Gao, Shaorong, Zhu, Jiyue, Kang, Jiuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868014/ https://www.ncbi.nlm.nih.gov/pubmed/31754456 http://dx.doi.org/10.1038/s41421-019-0116-8

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