Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D)

Cooperating gene mutations are typically required to transform normal cells enabling growth in soft agar or in immunodeficient mice. For example, mutations in Kras and transformation-related protein 53 (Trp53) are known to transform a variety of mesenchymal and epithelial cells in vitro and in vivo....

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Detalles Bibliográficos
Autores principales: Huang, Jianguo, Chen, Mark, Xu, Eric S., Luo, Lixia, Ma, Yan, Huang, Wesley, Floyd, Warren, Klann, Tyler S., Kim, So Young, Gersbach, Charles A., Cardona, Diana M., Kirsch, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868134/
https://www.ncbi.nlm.nih.gov/pubmed/31748650
http://dx.doi.org/10.1038/s41598-019-53572-w

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