Cargando…

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Metastatic castration-resistant prostate cancer (mCRPC) has a highly complex genomic landscape. With the recent development of novel treatments, accurate stratification strategies are needed. Here we present the whole-genome sequencing (WGS) analysis of fresh-frozen metastatic biopsies from 197 mCRP...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Dessel, Lisanne F., van Riet, Job, Smits, Minke, Zhu, Yanyun, Hamberg, Paul, van der Heijden, Michiel S., Bergman, Andries M., van Oort, Inge M., de Wit, Ronald, Voest, Emile E., Steeghs, Neeltje, Yamaguchi, Takafumi N., Livingstone, Julie, Boutros, Paul C., Martens, John W. M., Sleijfer, Stefan, Cuppen, Edwin, Zwart, Wilbert, van de Werken, Harmen J. G., Mehra, Niven, Lolkema, Martijn P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868175/ https://www.ncbi.nlm.nih.gov/pubmed/31748536 http://dx.doi.org/10.1038/s41467-019-13084-7

Ejemplares similares

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
por: van Riet, Job, et al.
Publicado: (2021)

11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration
por: Snaterse, Gido, et al.
Publicado: (2021)

ProteoDisco: a flexible R approach to generate customized protein databases for extended search space of novel and variant proteins in proteogenomic studies
por: van de Geer, Wesley S, et al.
Publicado: (2021)

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
por: Mendelaar, Pauline A. J., et al.
Publicado: (2021)

Author Correction: Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
por: Mendelaar, Pauline A. J., et al.
Publicado: (2021)

A prospective phase I multicentre randomized cross-over pharmacokinetic study to determine the effect of food on abiraterone pharmacokinetics
por: Lubberman, Floor J. E., et al.
Publicado: (2019)

Katdetectr: an R/bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detection
por: Hazelaar, Daan M, et al.
Publicado: (2023)

Pan-cancer whole-genome analyses of metastatic solid tumours
por: Priestley, Peter, et al.
Publicado: (2019)

Beta-adrenergic receptor blockade in angiosarcoma: Which beta-blocker to choose?
por: Embaby, Alaa, et al.
Publicado: (2022)

SAT-LB002 Steroid Metabolome Analysis Reveals 11-Ketotestosterone as the Most Abundant Androgen in Castration-Resistant Prostate Cancer Patients on Second-Line Therapies
por: Snaterse, Gido, et al.
Publicado: (2019)

The genomic and transcriptomic landscape of advanced renal cell cancer for individualized treatment strategies
por: de Joode, K., et al.
Publicado: (2023)

Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material
por: de Leng, Wendy W. J., et al.
Publicado: (2016)

Survival and Cost-Effectiveness of Trabectedin Compared to Ifosfamide Monotherapy in Advanced Soft Tissue Sarcoma Patients
por: Verboom, Michiel C., et al.
Publicado: (2019)

Preferences to receive unsolicited findings of germline genome sequencing in a large population of patients with cancer
por: Bijlsma, Rhode, et al.
Publicado: (2020)

Genomic Alterations Associated with Estrogen Receptor Pathway Activity in Metastatic Breast Cancer Have a Differential Impact on Downstream ER Signaling
por: Angus, Lindsay, et al.
Publicado: (2023)

Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients
por: Bins, Sander, et al.
Publicado: (2018)

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study
por: Weeber, Fleur, et al.
Publicado: (2017)

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
por: Jiao, Wei, et al.
Publicado: (2020)

Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
por: Jiao, Wei, et al.
Publicado: (2022)

The mutational footprints of cancer therapies
por: Pich, Oriol, et al.
Publicado: (2019)

Decreased exposure to sunitinib due to concomitant administration of ifosfamide: results of a phase I and pharmacokinetic study on the combination of sunitinib and ifosfamide in patients with advanced solid malignancies
por: Hamberg, P, et al.
Publicado: (2010)

The impact of patient characteristics on enzalutamide pharmacokinetics and how this relates to treatment toxicity and efficacy in metastatic prostate cancer patients
por: Benoist, Guillemette E., et al.
Publicado: (2020)

High‐throughput isolation of circulating tumor DNA: a comparison of automated platforms
por: van Dessel, Lisanne F., et al.
Publicado: (2018)

Intravital characterization of tumor cell migration in pancreatic cancer
por: Beerling, Evelyne, et al.
Publicado: (2016)

Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide
por: Podgoršek, Eva, et al.
Publicado: (2023)

A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer
por: Palit, Sander A. L., et al.
Publicado: (2021)

Continued Androgen Signalling Inhibition improves Cabazitaxel Efficacy in Prostate Cancer
por: Mout, Lisanne, et al.
Publicado: (2021)

FASTAFS: file system virtualisation of random access compressed FASTA files
por: Hoogstrate, Youri, et al.
Publicado: (2021)

Application of circulating tumor DNA in prospective clinical oncology trials – standardization of preanalytical conditions
por: van Dessel, Lisanne F., et al.
Publicado: (2017)

Radium-223 Treatment of Patients with Metastatic Castration Resistant Prostate Cancer: Biomarkers for Stratification and Response Evaluation
por: van der Zande, Kim, et al.
Publicado: (2021)

Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer
por: Vitale, Silvia R., et al.
Publicado: (2021)

Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond
por: Linder, Simon, et al.
Publicado: (2018)

Impacts of climate change on rice production in Africa and causes of simulated yield changes
por: van Oort, Pepijn A. J., et al.
Publicado: (2017)

Central venous access related adverse events after trabectedin infusions in soft tissue sarcoma patients; experience and management in a nationwide multi-center study
por: Verboom, Michiel C., et al.
Publicado: (2017)

High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments
por: Deger, Teoman, et al.
Publicado: (2021)

Prior PSMA PET-CT Imaging and Hounsfield Unit Impact on Tumor Yield and Success of Molecular Analyses from Bone Biopsies in Metastatic Prostate Cancer
por: Smits, Minke, et al.
Publicado: (2020)

The effect of chemotherapy on the exposure–response relation of abiraterone in metastatic castration‐resistant prostate cancer
por: Boerrigter, Emmy, et al.
Publicado: (2021)

Prospective bladder cancer infrastructure for experimental and observational research on bladder cancer: study protocol for the ‘trials within cohorts’ study ProBCI
por: Richters, Anke, et al.
Publicado: (2021)

Liquid Biopsies in Sarcoma Clinical Practice: Where Do We Stand?
por: van der Laan, Pia, et al.
Publicado: (2021)

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development
por: Dorssers, Lambert C. J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1bpni572evcm72u429q9jvip05