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Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings

Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both...

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Autores principales: Haque, Md Ahshanul, Platts-Mills, James A., Mduma, Estomih, Bodhidatta, Ladaporn, Bessong, Pascal, Shakoor, Sadia, Kang, Gagandeep, Kosek, Margaret N., Lima, Aldo A. M., Shrestha, Sanjaya K., Alam, Md. Ashraful, Havt, Alexandre, Samie, Amidou, Guerrant, Richard L., Lang, Dennis, Mahfuz, Mustafa, Bhutta, Zulfiqar A., Houpt, Eric R., Ahmed, Tahmeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868199/
https://www.ncbi.nlm.nih.gov/pubmed/31748573
http://dx.doi.org/10.1038/s41598-019-53533-3
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author Haque, Md Ahshanul
Platts-Mills, James A.
Mduma, Estomih
Bodhidatta, Ladaporn
Bessong, Pascal
Shakoor, Sadia
Kang, Gagandeep
Kosek, Margaret N.
Lima, Aldo A. M.
Shrestha, Sanjaya K.
Alam, Md. Ashraful
Havt, Alexandre
Samie, Amidou
Guerrant, Richard L.
Lang, Dennis
Mahfuz, Mustafa
Bhutta, Zulfiqar A.
Houpt, Eric R.
Ahmed, Tahmeed
author_facet Haque, Md Ahshanul
Platts-Mills, James A.
Mduma, Estomih
Bodhidatta, Ladaporn
Bessong, Pascal
Shakoor, Sadia
Kang, Gagandeep
Kosek, Margaret N.
Lima, Aldo A. M.
Shrestha, Sanjaya K.
Alam, Md. Ashraful
Havt, Alexandre
Samie, Amidou
Guerrant, Richard L.
Lang, Dennis
Mahfuz, Mustafa
Bhutta, Zulfiqar A.
Houpt, Eric R.
Ahmed, Tahmeed
author_sort Haque, Md Ahshanul
collection PubMed
description Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with Campylobacter jejuni/coli and Campylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of <6 years, lack of routine treatment of drinking water, and unimproved sanitation were associated with Campylobacter jejuni/coli infection. The cumulative burden of both Campylobacter jejuni/coli infections and Campylobacter species were associated with poor growth and increased intestinal inflammation.
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spelling pubmed-68681992019-12-04 Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings Haque, Md Ahshanul Platts-Mills, James A. Mduma, Estomih Bodhidatta, Ladaporn Bessong, Pascal Shakoor, Sadia Kang, Gagandeep Kosek, Margaret N. Lima, Aldo A. M. Shrestha, Sanjaya K. Alam, Md. Ashraful Havt, Alexandre Samie, Amidou Guerrant, Richard L. Lang, Dennis Mahfuz, Mustafa Bhutta, Zulfiqar A. Houpt, Eric R. Ahmed, Tahmeed Sci Rep Article Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with Campylobacter jejuni/coli and Campylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of <6 years, lack of routine treatment of drinking water, and unimproved sanitation were associated with Campylobacter jejuni/coli infection. The cumulative burden of both Campylobacter jejuni/coli infections and Campylobacter species were associated with poor growth and increased intestinal inflammation. Nature Publishing Group UK 2019-11-20 /pmc/articles/PMC6868199/ /pubmed/31748573 http://dx.doi.org/10.1038/s41598-019-53533-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Haque, Md Ahshanul
Platts-Mills, James A.
Mduma, Estomih
Bodhidatta, Ladaporn
Bessong, Pascal
Shakoor, Sadia
Kang, Gagandeep
Kosek, Margaret N.
Lima, Aldo A. M.
Shrestha, Sanjaya K.
Alam, Md. Ashraful
Havt, Alexandre
Samie, Amidou
Guerrant, Richard L.
Lang, Dennis
Mahfuz, Mustafa
Bhutta, Zulfiqar A.
Houpt, Eric R.
Ahmed, Tahmeed
Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
title Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
title_full Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
title_fullStr Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
title_full_unstemmed Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
title_short Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
title_sort determinants of campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868199/
https://www.ncbi.nlm.nih.gov/pubmed/31748573
http://dx.doi.org/10.1038/s41598-019-53533-3
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