Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine

In this work the permeability of a model asymmetric plasma membrane, for ions, water and the anti-cancer drugs cisplatin and gemcitabine is studied by means of all-atom molecular dynamics simulations. It is shown for the first time that permeability of the highly curved membrane increases from one t...

Descripción completa

Detalles Bibliográficos
Autores principales: Yesylevskyy, Semen, Rivel, Timothée, Ramseyer, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868207/
https://www.ncbi.nlm.nih.gov/pubmed/31748538
http://dx.doi.org/10.1038/s41598-019-53952-2
_version_ 1783472219647639552
author Yesylevskyy, Semen
Rivel, Timothée
Ramseyer, Christophe
author_facet Yesylevskyy, Semen
Rivel, Timothée
Ramseyer, Christophe
author_sort Yesylevskyy, Semen
collection PubMed
description In this work the permeability of a model asymmetric plasma membrane, for ions, water and the anti-cancer drugs cisplatin and gemcitabine is studied by means of all-atom molecular dynamics simulations. It is shown for the first time that permeability of the highly curved membrane increases from one to three orders of magnitude upon membrane bending depending on the compound and the sign of curvature. Our results suggest that the membrane curvature could be an important factor of drug translocation through the membrane.
format Online
Article
Text
id pubmed-6868207
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-68682072019-12-04 Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine Yesylevskyy, Semen Rivel, Timothée Ramseyer, Christophe Sci Rep Article In this work the permeability of a model asymmetric plasma membrane, for ions, water and the anti-cancer drugs cisplatin and gemcitabine is studied by means of all-atom molecular dynamics simulations. It is shown for the first time that permeability of the highly curved membrane increases from one to three orders of magnitude upon membrane bending depending on the compound and the sign of curvature. Our results suggest that the membrane curvature could be an important factor of drug translocation through the membrane. Nature Publishing Group UK 2019-11-20 /pmc/articles/PMC6868207/ /pubmed/31748538 http://dx.doi.org/10.1038/s41598-019-53952-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yesylevskyy, Semen
Rivel, Timothée
Ramseyer, Christophe
Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
title Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
title_full Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
title_fullStr Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
title_full_unstemmed Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
title_short Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
title_sort curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868207/
https://www.ncbi.nlm.nih.gov/pubmed/31748538
http://dx.doi.org/10.1038/s41598-019-53952-2
work_keys_str_mv AT yesylevskyysemen curvatureincreasespermeabilityoftheplasmamembraneforionswaterandtheanticancerdrugscisplatinandgemcitabine
AT riveltimothee curvatureincreasespermeabilityoftheplasmamembraneforionswaterandtheanticancerdrugscisplatinandgemcitabine
AT ramseyerchristophe curvatureincreasespermeabilityoftheplasmamembraneforionswaterandtheanticancerdrugscisplatinandgemcitabine

Ejemplares similares