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Intravitreal injection of adenosine A(2A) receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice
Diabetic retinopathy is a major complication of diabetes mellitus and a leading cause of blindness. The pathogenesis of diabetic retinopathy is accompanied by chronic low-grade inflammation. Evidence shows that the blockade of adenosine A(2A) receptors (A(2A)R) affords protection to the retina throu...
Autores principales: | Aires, Inês Dinis, Madeira, Maria Helena, Boia, Raquel, Rodrigues-Neves, Ana Catarina, Martins, Joana Margarida, Ambrósio, António Francisco, Santiago, Ana Raquel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868354/ https://www.ncbi.nlm.nih.gov/pubmed/31748653 http://dx.doi.org/10.1038/s41598-019-53627-y |
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