Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD(+)–SIRT1 pathway

Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its functions in tumorigenesis. Here, we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells. This inhibitory effect of pyruvate on c...

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Detalles Bibliográficos
Autores principales: Ma, Rui, Wu, Yinsheng, Zhai, Yansheng, Hu, Bicheng, Ma, Wei, Yang, Wenqiang, Yu, Qi, Chen, Zhen, Workman, Jerry L, Yu, Xilan, Li, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868375/
https://www.ncbi.nlm.nih.gov/pubmed/31598701
http://dx.doi.org/10.1093/nar/gkz864

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