GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival

The binding of p53-binding protein 1 (53BP1) to damaged chromatin is a critical event in non-homologous DNA end joining (NHEJ)-mediated DNA damage repair. Although several molecular pathways explaining how 53BP1 binds damaged chromatin have been described, the precise underlying mechanisms are still...

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Detalles Bibliográficos
Autores principales: Lu, Xiaopeng, Tang, Ming, Zhu, Qian, Yang, Qiaoyan, Li, Zhiming, Bao, Yantao, Liu, Ge, Hou, Tianyun, Lv, Yafei, Zhao, Ying, Wang, Haiying, Yang, Yang, Cheng, Zhongyi, Wen, He, Liu, Baohua, Xu, Xingzhi, Gu, Luo, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868394/
https://www.ncbi.nlm.nih.gov/pubmed/31612207
http://dx.doi.org/10.1093/nar/gkz897

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