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Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult
We describe a case of acute liver failure and myopericarditis due to herpes simplex virus–1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that wa...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868424/ https://www.ncbi.nlm.nih.gov/pubmed/31777756 http://dx.doi.org/10.1093/ofid/ofz465 |
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| author | Ikuta, Kevin Roychoudhury, Pavitra Xie, Hong Mcclurkan, Christopher L Walkiewicz, Magdalena Makhsous, Negar Huang, Meei-Li Beru, Yodit Alam, Mariam Shepherd, Amanda Lamotte, Eric D Patel, Kevin Morris, Amy Ҫoruh, Başak Yu, Lei Bhattacharya, Renuka Cheng, Rex Walter, Roland B Limaye, Ajit P Lockwood, Christina M Holland, Steven M Rakita, Robert M Koelle, David M Greninger, Alexander L |
| author_facet | Ikuta, Kevin Roychoudhury, Pavitra Xie, Hong Mcclurkan, Christopher L Walkiewicz, Magdalena Makhsous, Negar Huang, Meei-Li Beru, Yodit Alam, Mariam Shepherd, Amanda Lamotte, Eric D Patel, Kevin Morris, Amy Ҫoruh, Başak Yu, Lei Bhattacharya, Renuka Cheng, Rex Walter, Roland B Limaye, Ajit P Lockwood, Christina M Holland, Steven M Rakita, Robert M Koelle, David M Greninger, Alexander L |
| author_sort | Ikuta, Kevin |
| collection | PubMed |
| description | We describe a case of acute liver failure and myopericarditis due to herpes simplex virus–1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response. |
| format | Online Article Text |
| id | pubmed-6868424 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68684242019-11-27 Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult Ikuta, Kevin Roychoudhury, Pavitra Xie, Hong Mcclurkan, Christopher L Walkiewicz, Magdalena Makhsous, Negar Huang, Meei-Li Beru, Yodit Alam, Mariam Shepherd, Amanda Lamotte, Eric D Patel, Kevin Morris, Amy Ҫoruh, Başak Yu, Lei Bhattacharya, Renuka Cheng, Rex Walter, Roland B Limaye, Ajit P Lockwood, Christina M Holland, Steven M Rakita, Robert M Koelle, David M Greninger, Alexander L Open Forum Infect Dis Brief Report We describe a case of acute liver failure and myopericarditis due to herpes simplex virus–1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response. Oxford University Press 2019-11-05 /pmc/articles/PMC6868424/ /pubmed/31777756 http://dx.doi.org/10.1093/ofid/ofz465 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Ikuta, Kevin Roychoudhury, Pavitra Xie, Hong Mcclurkan, Christopher L Walkiewicz, Magdalena Makhsous, Negar Huang, Meei-Li Beru, Yodit Alam, Mariam Shepherd, Amanda Lamotte, Eric D Patel, Kevin Morris, Amy Ҫoruh, Başak Yu, Lei Bhattacharya, Renuka Cheng, Rex Walter, Roland B Limaye, Ajit P Lockwood, Christina M Holland, Steven M Rakita, Robert M Koelle, David M Greninger, Alexander L Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult |
| title | Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult |
| title_full | Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult |
| title_fullStr | Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult |
| title_full_unstemmed | Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult |
| title_short | Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult |
| title_sort | trillions and trillions: herpes simplex virus–1 hepatitis in an immunocompetent adult |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868424/ https://www.ncbi.nlm.nih.gov/pubmed/31777756 http://dx.doi.org/10.1093/ofid/ofz465 |
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