Differences of Microglia in the Brain and the Spinal Cord

Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulating evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and biological functions. Although this is a very int...

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Autores principales: Xuan, Fang-Ling, Chithanathan, Keerthana, Lilleväli, Kersti, Yuan, Xiaodong, Tian, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868492/
https://www.ncbi.nlm.nih.gov/pubmed/31803021
http://dx.doi.org/10.3389/fncel.2019.00504
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author Xuan, Fang-Ling
Chithanathan, Keerthana
Lilleväli, Kersti
Yuan, Xiaodong
Tian, Li
author_facet Xuan, Fang-Ling
Chithanathan, Keerthana
Lilleväli, Kersti
Yuan, Xiaodong
Tian, Li
author_sort Xuan, Fang-Ling
collection PubMed
description Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulating evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and biological functions. Although this is a very interesting phenomenon, the underlying mechanisms and its significance for neurological diseases in association with behavioral and cognitive changes are still unclear. How microglia differ between these two regions and whether such diversity may contribute to CNS development and functions as well as neurological diseases will be discussed in this Perspective.
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spelling pubmed-68684922019-12-04 Differences of Microglia in the Brain and the Spinal Cord Xuan, Fang-Ling Chithanathan, Keerthana Lilleväli, Kersti Yuan, Xiaodong Tian, Li Front Cell Neurosci Neuroscience Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulating evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and biological functions. Although this is a very interesting phenomenon, the underlying mechanisms and its significance for neurological diseases in association with behavioral and cognitive changes are still unclear. How microglia differ between these two regions and whether such diversity may contribute to CNS development and functions as well as neurological diseases will be discussed in this Perspective. Frontiers Media S.A. 2019-11-14 /pmc/articles/PMC6868492/ /pubmed/31803021 http://dx.doi.org/10.3389/fncel.2019.00504 Text en Copyright © 2019 Xuan, Chithanathan, Lilleväli, Yuan and Tian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Xuan, Fang-Ling
Chithanathan, Keerthana
Lilleväli, Kersti
Yuan, Xiaodong
Tian, Li
Differences of Microglia in the Brain and the Spinal Cord
title Differences of Microglia in the Brain and the Spinal Cord
title_full Differences of Microglia in the Brain and the Spinal Cord
title_fullStr Differences of Microglia in the Brain and the Spinal Cord
title_full_unstemmed Differences of Microglia in the Brain and the Spinal Cord
title_short Differences of Microglia in the Brain and the Spinal Cord
title_sort differences of microglia in the brain and the spinal cord
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868492/
https://www.ncbi.nlm.nih.gov/pubmed/31803021
http://dx.doi.org/10.3389/fncel.2019.00504
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