Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC

[Image: see text] A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne–nitrone cycloaddition reactions has been synthesized. These nitrone–AuNPs were characterized in detail using (1)H nuclear ma...

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Autores principales: Ghiassian, Sara, Yu, Lihai, Gobbo, Pierangelo, Nazemi, Ali, Romagnoli, Tommaso, Luo, Wilson, Luyt, Leonard G., Workentin, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868604/
https://www.ncbi.nlm.nih.gov/pubmed/31763533
http://dx.doi.org/10.1021/acsomega.9b02322
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author Ghiassian, Sara
Yu, Lihai
Gobbo, Pierangelo
Nazemi, Ali
Romagnoli, Tommaso
Luo, Wilson
Luyt, Leonard G.
Workentin, Mark S.
author_facet Ghiassian, Sara
Yu, Lihai
Gobbo, Pierangelo
Nazemi, Ali
Romagnoli, Tommaso
Luo, Wilson
Luyt, Leonard G.
Workentin, Mark S.
author_sort Ghiassian, Sara
collection PubMed
description [Image: see text] A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne–nitrone cycloaddition reactions has been synthesized. These nitrone–AuNPs were characterized in detail using (1)H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone–AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes.
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spelling pubmed-68686042019-11-22 Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC Ghiassian, Sara Yu, Lihai Gobbo, Pierangelo Nazemi, Ali Romagnoli, Tommaso Luo, Wilson Luyt, Leonard G. Workentin, Mark S. ACS Omega [Image: see text] A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne–nitrone cycloaddition reactions has been synthesized. These nitrone–AuNPs were characterized in detail using (1)H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone–AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes. American Chemical Society 2019-11-08 /pmc/articles/PMC6868604/ /pubmed/31763533 http://dx.doi.org/10.1021/acsomega.9b02322 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ghiassian, Sara
Yu, Lihai
Gobbo, Pierangelo
Nazemi, Ali
Romagnoli, Tommaso
Luo, Wilson
Luyt, Leonard G.
Workentin, Mark S.
Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC
title Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC
title_full Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC
title_fullStr Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC
title_full_unstemmed Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC
title_short Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as (18)F-Labeled Positron Emission Tomography Probes via I-SPANC
title_sort nitrone-modified gold nanoparticles: synthesis, characterization, and their potential as (18)f-labeled positron emission tomography probes via i-spanc
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868604/
https://www.ncbi.nlm.nih.gov/pubmed/31763533
http://dx.doi.org/10.1021/acsomega.9b02322
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