Cargando…
Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
BACKGROUND AND AIMS: Haemodynamic changes during endotracheal intubation are major concerns in general anaesthesia This study compared the efficacy of intranasal and intravenous dexmedetomidine (DEX) to attenuate the stress response of laryngoscopy and endotracheal intubation. METHODS: In this prosp...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868674/ https://www.ncbi.nlm.nih.gov/pubmed/31772400 http://dx.doi.org/10.4103/ija.IJA_320_19 |
_version_ | 1783472317424205824 |
---|---|
author | Niyogi, Saikat Biswas, Asit Chakraborty, Indrani Chakraborty, Soumya Acharjee, Amita |
author_facet | Niyogi, Saikat Biswas, Asit Chakraborty, Indrani Chakraborty, Soumya Acharjee, Amita |
author_sort | Niyogi, Saikat |
collection | PubMed |
description | BACKGROUND AND AIMS: Haemodynamic changes during endotracheal intubation are major concerns in general anaesthesia This study compared the efficacy of intranasal and intravenous dexmedetomidine (DEX) to attenuate the stress response of laryngoscopy and endotracheal intubation. METHODS: In this prospective, randomised, double-blinded study, 70 adults were divided into two groups [Group D(IV)(n=35) and Group D(IN)(n=35)]. D(IV) group received intravenous dexmedetomidine (DEX) infusion (0.5 μg/kg) over 40 min and D(IN) group received intranasal dexmedetomidine (1 μg/kg) 40 min before induction. The primary objective was the comparison the mean arterial pressure (MAP) between two groups from 40 min before induction at every 10 min intervals till induction of anaesthesia, at the time of intubation, thereafter every 1 min interval till 5 min, at 7 min and 10 min after intubation. The secondary outcomes were comparison of heart rate, systolic and diastolic blood pressure along with sedation and other adverse effects. Statistical analysis was with Statistica 6.0 and Graph Pad prism version 5. RESULTS: In both the groups, all the haemodynamic parameters were maintained within (20% of baseline values) throughout the study period. There was no statistically significant difference in MAP between two groups (P>0.05). Preoperative sedation score was significantly higher in the D(IV) group than the D(IN) group (P = 0.014). CONCLUSION: Like IV DEX, intranasal DEX can also attenuate the haemodynamic stress responses of laryngoscopy and endotracheal intubation without significant differences in MAP between two groups. |
format | Online Article Text |
id | pubmed-6868674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-68686742019-11-26 Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route Niyogi, Saikat Biswas, Asit Chakraborty, Indrani Chakraborty, Soumya Acharjee, Amita Indian J Anaesth Original Article BACKGROUND AND AIMS: Haemodynamic changes during endotracheal intubation are major concerns in general anaesthesia This study compared the efficacy of intranasal and intravenous dexmedetomidine (DEX) to attenuate the stress response of laryngoscopy and endotracheal intubation. METHODS: In this prospective, randomised, double-blinded study, 70 adults were divided into two groups [Group D(IV)(n=35) and Group D(IN)(n=35)]. D(IV) group received intravenous dexmedetomidine (DEX) infusion (0.5 μg/kg) over 40 min and D(IN) group received intranasal dexmedetomidine (1 μg/kg) 40 min before induction. The primary objective was the comparison the mean arterial pressure (MAP) between two groups from 40 min before induction at every 10 min intervals till induction of anaesthesia, at the time of intubation, thereafter every 1 min interval till 5 min, at 7 min and 10 min after intubation. The secondary outcomes were comparison of heart rate, systolic and diastolic blood pressure along with sedation and other adverse effects. Statistical analysis was with Statistica 6.0 and Graph Pad prism version 5. RESULTS: In both the groups, all the haemodynamic parameters were maintained within (20% of baseline values) throughout the study period. There was no statistically significant difference in MAP between two groups (P>0.05). Preoperative sedation score was significantly higher in the D(IV) group than the D(IN) group (P = 0.014). CONCLUSION: Like IV DEX, intranasal DEX can also attenuate the haemodynamic stress responses of laryngoscopy and endotracheal intubation without significant differences in MAP between two groups. Wolters Kluwer - Medknow 2019-11 2019-11-08 /pmc/articles/PMC6868674/ /pubmed/31772400 http://dx.doi.org/10.4103/ija.IJA_320_19 Text en Copyright: © 2019 Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Niyogi, Saikat Biswas, Asit Chakraborty, Indrani Chakraborty, Soumya Acharjee, Amita Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route |
title | Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route |
title_full | Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route |
title_fullStr | Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route |
title_full_unstemmed | Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route |
title_short | Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route |
title_sort | attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: a comparison between intravenous and intranasal route |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868674/ https://www.ncbi.nlm.nih.gov/pubmed/31772400 http://dx.doi.org/10.4103/ija.IJA_320_19 |
work_keys_str_mv | AT niyogisaikat attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute AT biswasasit attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute AT chakrabortyindrani attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute AT chakrabortysoumya attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute AT acharjeeamita attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute |