Cargando…

Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route

BACKGROUND AND AIMS: Haemodynamic changes during endotracheal intubation are major concerns in general anaesthesia This study compared the efficacy of intranasal and intravenous dexmedetomidine (DEX) to attenuate the stress response of laryngoscopy and endotracheal intubation. METHODS: In this prosp...

Descripción completa

Detalles Bibliográficos
Autores principales: Niyogi, Saikat, Biswas, Asit, Chakraborty, Indrani, Chakraborty, Soumya, Acharjee, Amita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868674/
https://www.ncbi.nlm.nih.gov/pubmed/31772400
http://dx.doi.org/10.4103/ija.IJA_320_19
_version_ 1783472317424205824
author Niyogi, Saikat
Biswas, Asit
Chakraborty, Indrani
Chakraborty, Soumya
Acharjee, Amita
author_facet Niyogi, Saikat
Biswas, Asit
Chakraborty, Indrani
Chakraborty, Soumya
Acharjee, Amita
author_sort Niyogi, Saikat
collection PubMed
description BACKGROUND AND AIMS: Haemodynamic changes during endotracheal intubation are major concerns in general anaesthesia This study compared the efficacy of intranasal and intravenous dexmedetomidine (DEX) to attenuate the stress response of laryngoscopy and endotracheal intubation. METHODS: In this prospective, randomised, double-blinded study, 70 adults were divided into two groups [Group D(IV)(n=35) and Group D(IN)(n=35)]. D(IV) group received intravenous dexmedetomidine (DEX) infusion (0.5 μg/kg) over 40 min and D(IN) group received intranasal dexmedetomidine (1 μg/kg) 40 min before induction. The primary objective was the comparison the mean arterial pressure (MAP) between two groups from 40 min before induction at every 10 min intervals till induction of anaesthesia, at the time of intubation, thereafter every 1 min interval till 5 min, at 7 min and 10 min after intubation. The secondary outcomes were comparison of heart rate, systolic and diastolic blood pressure along with sedation and other adverse effects. Statistical analysis was with Statistica 6.0 and Graph Pad prism version 5. RESULTS: In both the groups, all the haemodynamic parameters were maintained within (20% of baseline values) throughout the study period. There was no statistically significant difference in MAP between two groups (P>0.05). Preoperative sedation score was significantly higher in the D(IV) group than the D(IN) group (P = 0.014). CONCLUSION: Like IV DEX, intranasal DEX can also attenuate the haemodynamic stress responses of laryngoscopy and endotracheal intubation without significant differences in MAP between two groups.
format Online
Article
Text
id pubmed-6868674
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-68686742019-11-26 Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route Niyogi, Saikat Biswas, Asit Chakraborty, Indrani Chakraborty, Soumya Acharjee, Amita Indian J Anaesth Original Article BACKGROUND AND AIMS: Haemodynamic changes during endotracheal intubation are major concerns in general anaesthesia This study compared the efficacy of intranasal and intravenous dexmedetomidine (DEX) to attenuate the stress response of laryngoscopy and endotracheal intubation. METHODS: In this prospective, randomised, double-blinded study, 70 adults were divided into two groups [Group D(IV)(n=35) and Group D(IN)(n=35)]. D(IV) group received intravenous dexmedetomidine (DEX) infusion (0.5 μg/kg) over 40 min and D(IN) group received intranasal dexmedetomidine (1 μg/kg) 40 min before induction. The primary objective was the comparison the mean arterial pressure (MAP) between two groups from 40 min before induction at every 10 min intervals till induction of anaesthesia, at the time of intubation, thereafter every 1 min interval till 5 min, at 7 min and 10 min after intubation. The secondary outcomes were comparison of heart rate, systolic and diastolic blood pressure along with sedation and other adverse effects. Statistical analysis was with Statistica 6.0 and Graph Pad prism version 5. RESULTS: In both the groups, all the haemodynamic parameters were maintained within (20% of baseline values) throughout the study period. There was no statistically significant difference in MAP between two groups (P>0.05). Preoperative sedation score was significantly higher in the D(IV) group than the D(IN) group (P = 0.014). CONCLUSION: Like IV DEX, intranasal DEX can also attenuate the haemodynamic stress responses of laryngoscopy and endotracheal intubation without significant differences in MAP between two groups. Wolters Kluwer - Medknow 2019-11 2019-11-08 /pmc/articles/PMC6868674/ /pubmed/31772400 http://dx.doi.org/10.4103/ija.IJA_320_19 Text en Copyright: © 2019 Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Niyogi, Saikat
Biswas, Asit
Chakraborty, Indrani
Chakraborty, Soumya
Acharjee, Amita
Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
title Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
title_full Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
title_fullStr Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
title_full_unstemmed Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
title_short Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route
title_sort attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: a comparison between intravenous and intranasal route
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868674/
https://www.ncbi.nlm.nih.gov/pubmed/31772400
http://dx.doi.org/10.4103/ija.IJA_320_19
work_keys_str_mv AT niyogisaikat attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute
AT biswasasit attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute
AT chakrabortyindrani attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute
AT chakrabortysoumya attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute
AT acharjeeamita attenuationofhaemodynamicresponsestolaryngoscopyandendotrachealintubationwithdexmedetomidineacomparisonbetweenintravenousandintranasalroute