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Epigenetic modifications of histones in cancer
The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Spe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868810/ https://www.ncbi.nlm.nih.gov/pubmed/31747960 http://dx.doi.org/10.1186/s13059-019-1870-5 |
| _version_ | 1783472348991586304 |
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| author | Zhao, Zibo Shilatifard, Ali |
| author_facet | Zhao, Zibo Shilatifard, Ali |
| author_sort | Zhao, Zibo |
| collection | PubMed |
| description | The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries and modifications that are involved in cancer development and progression, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications. |
| format | Online Article Text |
| id | pubmed-6868810 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68688102019-12-12 Epigenetic modifications of histones in cancer Zhao, Zibo Shilatifard, Ali Genome Biol Review The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries and modifications that are involved in cancer development and progression, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications. BioMed Central 2019-11-20 /pmc/articles/PMC6868810/ /pubmed/31747960 http://dx.doi.org/10.1186/s13059-019-1870-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Zhao, Zibo Shilatifard, Ali Epigenetic modifications of histones in cancer |
| title | Epigenetic modifications of histones in cancer |
| title_full | Epigenetic modifications of histones in cancer |
| title_fullStr | Epigenetic modifications of histones in cancer |
| title_full_unstemmed | Epigenetic modifications of histones in cancer |
| title_short | Epigenetic modifications of histones in cancer |
| title_sort | epigenetic modifications of histones in cancer |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868810/ https://www.ncbi.nlm.nih.gov/pubmed/31747960 http://dx.doi.org/10.1186/s13059-019-1870-5 |
| work_keys_str_mv | AT zhaozibo epigeneticmodificationsofhistonesincancer AT shilatifardali epigeneticmodificationsofhistonesincancer |