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Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia

[Image: see text] Many conotoxins, natural peptides of marine cone snails, have been identified to target neurons. Here, we provide data on pharmacological families of the conotoxins of 11 species of cone snails collected in Bali. The identified definitive pharmacological families possibly targeting...

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Autores principales: Sudewi, Anak A. R., Susilawathi, Ni M., Mahardika, Bayu K., Mahendra, Agung N., Pharmawati, Made, Phuong, Mark A., Mahardika, Gusti N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868881/
https://www.ncbi.nlm.nih.gov/pubmed/31763573
http://dx.doi.org/10.1021/acsomega.9b03122
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author Sudewi, Anak A. R.
Susilawathi, Ni M.
Mahardika, Bayu K.
Mahendra, Agung N.
Pharmawati, Made
Phuong, Mark A.
Mahardika, Gusti N.
author_facet Sudewi, Anak A. R.
Susilawathi, Ni M.
Mahardika, Bayu K.
Mahendra, Agung N.
Pharmawati, Made
Phuong, Mark A.
Mahardika, Gusti N.
author_sort Sudewi, Anak A. R.
collection PubMed
description [Image: see text] Many conotoxins, natural peptides of marine cone snails, have been identified to target neurons. Here, we provide data on pharmacological families of the conotoxins of 11 species of cone snails collected in Bali. The identified definitive pharmacological families possibly targeting neuronal tissues were α (alpha), ι (iota), κ (kappa), and ρ (rho). These classes shall target nicotinic acetylcholine receptors, voltage-gated Na channels, voltage-gated K channels, and α1-adrenoceptors, respectively. The VI/VII-O3 conotoxins might be prospected as an inhibitor of N-methyl-d-aspartate. Con-ikot-ikot could be applied as an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor blocker medicine. The definitive pharmacology classes of conotoxins as well as those yet to be elucidated need to be further established and verified.
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spelling pubmed-68688812019-11-22 Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia Sudewi, Anak A. R. Susilawathi, Ni M. Mahardika, Bayu K. Mahendra, Agung N. Pharmawati, Made Phuong, Mark A. Mahardika, Gusti N. ACS Omega [Image: see text] Many conotoxins, natural peptides of marine cone snails, have been identified to target neurons. Here, we provide data on pharmacological families of the conotoxins of 11 species of cone snails collected in Bali. The identified definitive pharmacological families possibly targeting neuronal tissues were α (alpha), ι (iota), κ (kappa), and ρ (rho). These classes shall target nicotinic acetylcholine receptors, voltage-gated Na channels, voltage-gated K channels, and α1-adrenoceptors, respectively. The VI/VII-O3 conotoxins might be prospected as an inhibitor of N-methyl-d-aspartate. Con-ikot-ikot could be applied as an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor blocker medicine. The definitive pharmacology classes of conotoxins as well as those yet to be elucidated need to be further established and verified. American Chemical Society 2019-11-06 /pmc/articles/PMC6868881/ /pubmed/31763573 http://dx.doi.org/10.1021/acsomega.9b03122 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Sudewi, Anak A. R.
Susilawathi, Ni M.
Mahardika, Bayu K.
Mahendra, Agung N.
Pharmawati, Made
Phuong, Mark A.
Mahardika, Gusti N.
Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia
title Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia
title_full Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia
title_fullStr Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia
title_full_unstemmed Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia
title_short Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia
title_sort selecting potential neuronal drug leads from conotoxins of various venomous marine cone snails in bali, indonesia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868881/
https://www.ncbi.nlm.nih.gov/pubmed/31763573
http://dx.doi.org/10.1021/acsomega.9b03122
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