Allogeneic mesenchymal stem cells for treatment of severe burn injury

The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 ...

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Autores principales: Jeschke, Marc G., Rehou, Sarah, McCann, Matthew R., Shahrokhi, Shahriar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869190/
https://www.ncbi.nlm.nih.gov/pubmed/31752987
http://dx.doi.org/10.1186/s13287-019-1465-9
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author Jeschke, Marc G.
Rehou, Sarah
McCann, Matthew R.
Shahrokhi, Shahriar
author_facet Jeschke, Marc G.
Rehou, Sarah
McCann, Matthew R.
Shahrokhi, Shahriar
author_sort Jeschke, Marc G.
collection PubMed
description The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential.
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spelling pubmed-68691902019-12-12 Allogeneic mesenchymal stem cells for treatment of severe burn injury Jeschke, Marc G. Rehou, Sarah McCann, Matthew R. Shahrokhi, Shahriar Stem Cell Res Ther Short Report The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries. This report describes a patient with a severe burn injury whose wounds did not heal with over 18 months of conventional burn care. When treated with allogeneic MSCs, wound healing accelerated with no adverse treatment complications. Wound sites showed no evidence of keloids or hypertrophic formation during a 6-year follow-up period. This therapeutic use of allogeneic MSCs for large non-healing burn wounds was deemed safe and effective and has great treatment potential. BioMed Central 2019-11-21 /pmc/articles/PMC6869190/ /pubmed/31752987 http://dx.doi.org/10.1186/s13287-019-1465-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Jeschke, Marc G.
Rehou, Sarah
McCann, Matthew R.
Shahrokhi, Shahriar
Allogeneic mesenchymal stem cells for treatment of severe burn injury
title Allogeneic mesenchymal stem cells for treatment of severe burn injury
title_full Allogeneic mesenchymal stem cells for treatment of severe burn injury
title_fullStr Allogeneic mesenchymal stem cells for treatment of severe burn injury
title_full_unstemmed Allogeneic mesenchymal stem cells for treatment of severe burn injury
title_short Allogeneic mesenchymal stem cells for treatment of severe burn injury
title_sort allogeneic mesenchymal stem cells for treatment of severe burn injury
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869190/
https://www.ncbi.nlm.nih.gov/pubmed/31752987
http://dx.doi.org/10.1186/s13287-019-1465-9
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