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Extracellular vesicles in urologic malignancies—Implementations for future cancer care

Extracellular vesicles (EVs), a heterogeneous group of vesicles differing in size and shape, cargo content and function, are membrane‐bound and nano‐sized vesicles that could be released by nearly all variations of cells. EVs have gained considerable attention in the past decades for their functions...

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Autores principales: Wu, Zhangsong, Zhang, Zhiqiang, Xia, Wuchao, Cai, Jiajia, Li, Yuqing, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869217/
https://www.ncbi.nlm.nih.gov/pubmed/31469460
http://dx.doi.org/10.1111/cpr.12659
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author Wu, Zhangsong
Zhang, Zhiqiang
Xia, Wuchao
Cai, Jiajia
Li, Yuqing
Wu, Song
author_facet Wu, Zhangsong
Zhang, Zhiqiang
Xia, Wuchao
Cai, Jiajia
Li, Yuqing
Wu, Song
author_sort Wu, Zhangsong
collection PubMed
description Extracellular vesicles (EVs), a heterogeneous group of vesicles differing in size and shape, cargo content and function, are membrane‐bound and nano‐sized vesicles that could be released by nearly all variations of cells. EVs have gained considerable attention in the past decades for their functions in modulating intercellular signalling and roles as potential pools for the novel diagnostic and prognostic biomarkers, as well as therapeutic targets in several cancers including urological neoplasms. In general, human and animal cells both can release distinct types of EVs, including exosomes, microvesicles, oncosomes and large oncosomes, and apoptotic bodies, while the content of EVs can be divided into proteins, lipids and nucleic acids. However, the lack of standard methods for isolation and detection platforms rein the widespread usage in clinical applications warranted furthermore investigations in the development of reliable, specific and sensitive isolation techniques. Whether and how the EVs work has become pertinent issues. With the aid of high‐throughput proteomics or genomics methods, a fully understanding of contents contained in EVs from urogenital tumours, beyond all doubt, will improve our ability to identify the complex genomic alterations in the process of cancer and, in turn, contribute to detect potential therapeutic target and then provide personalization strategy for patient.
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spelling pubmed-68692172020-03-13 Extracellular vesicles in urologic malignancies—Implementations for future cancer care Wu, Zhangsong Zhang, Zhiqiang Xia, Wuchao Cai, Jiajia Li, Yuqing Wu, Song Cell Prolif Review Extracellular vesicles (EVs), a heterogeneous group of vesicles differing in size and shape, cargo content and function, are membrane‐bound and nano‐sized vesicles that could be released by nearly all variations of cells. EVs have gained considerable attention in the past decades for their functions in modulating intercellular signalling and roles as potential pools for the novel diagnostic and prognostic biomarkers, as well as therapeutic targets in several cancers including urological neoplasms. In general, human and animal cells both can release distinct types of EVs, including exosomes, microvesicles, oncosomes and large oncosomes, and apoptotic bodies, while the content of EVs can be divided into proteins, lipids and nucleic acids. However, the lack of standard methods for isolation and detection platforms rein the widespread usage in clinical applications warranted furthermore investigations in the development of reliable, specific and sensitive isolation techniques. Whether and how the EVs work has become pertinent issues. With the aid of high‐throughput proteomics or genomics methods, a fully understanding of contents contained in EVs from urogenital tumours, beyond all doubt, will improve our ability to identify the complex genomic alterations in the process of cancer and, in turn, contribute to detect potential therapeutic target and then provide personalization strategy for patient. John Wiley and Sons Inc. 2019-08-30 /pmc/articles/PMC6869217/ /pubmed/31469460 http://dx.doi.org/10.1111/cpr.12659 Text en © 2019 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wu, Zhangsong
Zhang, Zhiqiang
Xia, Wuchao
Cai, Jiajia
Li, Yuqing
Wu, Song
Extracellular vesicles in urologic malignancies—Implementations for future cancer care
title Extracellular vesicles in urologic malignancies—Implementations for future cancer care
title_full Extracellular vesicles in urologic malignancies—Implementations for future cancer care
title_fullStr Extracellular vesicles in urologic malignancies—Implementations for future cancer care
title_full_unstemmed Extracellular vesicles in urologic malignancies—Implementations for future cancer care
title_short Extracellular vesicles in urologic malignancies—Implementations for future cancer care
title_sort extracellular vesicles in urologic malignancies—implementations for future cancer care
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869217/
https://www.ncbi.nlm.nih.gov/pubmed/31469460
http://dx.doi.org/10.1111/cpr.12659
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