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Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach
R-loops are three-stranded DNA:RNA hybrids that are implicated in many nuclear processes. While R-loops may have physiological roles, the formation of stable, aberrant R-loops has been observed in neurological disorders and cancers. Current methods to assess their genome-wide distribution rely on af...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6870988/ https://www.ncbi.nlm.nih.gov/pubmed/31665646 http://dx.doi.org/10.1016/j.celrep.2019.09.052 |