A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control differentiation of the two sexes. The female transcript, unlike the male, contains an exon (exon 5) whose sequence is highl...

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Detalles Bibliográficos
Autores principales: Kyrou, Kyros, Hammond, Andrew M, Galizi, Roberto, Kranjc, Nace, Burt, Austin, Beaghton, Andrea K, Nolan, Tony, Crisanti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871539/
https://www.ncbi.nlm.nih.gov/pubmed/30247490
http://dx.doi.org/10.1038/nbt.4245

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