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Liver organoids: from basic research to therapeutic applications

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex arc...

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Detalles Bibliográficos
Autores principales: Prior, Nicole, Inacio, Patricia, Huch, Meritxell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872443/
https://www.ncbi.nlm.nih.gov/pubmed/31300517
http://dx.doi.org/10.1136/gutjnl-2019-319256
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author Prior, Nicole
Inacio, Patricia
Huch, Meritxell
author_facet Prior, Nicole
Inacio, Patricia
Huch, Meritxell
author_sort Prior, Nicole
collection PubMed
description Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications.
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spelling pubmed-68724432019-12-04 Liver organoids: from basic research to therapeutic applications Prior, Nicole Inacio, Patricia Huch, Meritxell Gut Recent Advances in Basic Science Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications. BMJ Publishing Group 2019-12 2019-07-12 /pmc/articles/PMC6872443/ /pubmed/31300517 http://dx.doi.org/10.1136/gutjnl-2019-319256 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Recent Advances in Basic Science
Prior, Nicole
Inacio, Patricia
Huch, Meritxell
Liver organoids: from basic research to therapeutic applications
title Liver organoids: from basic research to therapeutic applications
title_full Liver organoids: from basic research to therapeutic applications
title_fullStr Liver organoids: from basic research to therapeutic applications
title_full_unstemmed Liver organoids: from basic research to therapeutic applications
title_short Liver organoids: from basic research to therapeutic applications
title_sort liver organoids: from basic research to therapeutic applications
topic Recent Advances in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872443/
https://www.ncbi.nlm.nih.gov/pubmed/31300517
http://dx.doi.org/10.1136/gutjnl-2019-319256
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