Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

Immune disease variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states is unknown. We stimulated T cells and macrophages in the presence of thirteen cytokines and profiled active and open chromatin regions. T cell...

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Detalles Bibliográficos
Autores principales: Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Rowan, Wendy C., Nakic, Nikolina, Esparza-Gordillo, Jorge, Bossini-Castillo, Lara, Tough, David F., Larminie, Christopher GC, Bronson, Paola G., Willé, David, Trynka, Gosia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872452/
https://www.ncbi.nlm.nih.gov/pubmed/31548716
http://dx.doi.org/10.1038/s41588-019-0493-9

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