Cargando…

Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism

OBJECTIVE: The interaction between thyroid status and brown adipose tissue (BAT) activation is complex. We assessed the effect of autoimmune hypothyroidism (ATD) in female children on BAT activation, measured using infrared thermography. DESIGN: Twenty-six female participants (14 with ATD and 12 hea...

Descripción completa

Detalles Bibliográficos
Autores principales: Law, James M, Morris, David E, Astle, Valerie, Finn, Ellie, Muros, José Joaquín, Robinson, Lindsay J, Randell, Tabitha, Denvir, Louise, Symonds, Michael E, Budge, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872489/
https://www.ncbi.nlm.nih.gov/pubmed/31777769
http://dx.doi.org/10.1210/js.2019-00342
_version_ 1783472493512622080
author Law, James M
Morris, David E
Astle, Valerie
Finn, Ellie
Muros, José Joaquín
Robinson, Lindsay J
Randell, Tabitha
Denvir, Louise
Symonds, Michael E
Budge, Helen
author_facet Law, James M
Morris, David E
Astle, Valerie
Finn, Ellie
Muros, José Joaquín
Robinson, Lindsay J
Randell, Tabitha
Denvir, Louise
Symonds, Michael E
Budge, Helen
author_sort Law, James M
collection PubMed
description OBJECTIVE: The interaction between thyroid status and brown adipose tissue (BAT) activation is complex. We assessed the effect of autoimmune hypothyroidism (ATD) in female children on BAT activation, measured using infrared thermography. DESIGN: Twenty-six female participants (14 with ATD and 12 healthy controls) between 5 and 17 years of age attended a single study session. Thermal images were taken of the supraclavicular region before, and after, the introduction of a cool stimulus. RESULTS: Participants with ATD had lower resting (hypothyroid, 34.9 ± 0.7°C; control, 35.4 ± 0.5°C; P = 0.03) and stimulated (hypothyroid, 35.0 ± 0.6°C; control, 35.5 ± 0.5°C; P = 0.04) supraclavicular temperatures compared with controls, but there was no difference between groups in the temperature increase with stimulation. BAT activation, calculated as the relative temperature change comparing the supraclavicular temperature to a sternal reference region, was reduced in participants with ATD (hypothyroid, 0.1 ± 0.1°C; control, 0.2 ± 0.2°C; P = 0.04). Children with ATD were frequently biochemically euthyroid due to replacement therapy, but, despite this, increased relative supraclavicular temperature was closely associated with increased TSH (r = 0.7, P = 0.01) concentrations. CONCLUSIONS: Girls with ATD had an attenuated thermogenic response to cold stimulation compared with healthy controls, but, contrary to expectation, those with suboptimal biochemical control (with higher TSH) showed increased BAT activation. This suggests that the underlying disease process may have a negative effect on BAT response, but high levels of TSH can mitigate, and even stimulate, BAT activity. In summary, thyroid status is a complex determinant of BAT activity in girls with ATD.
format Online
Article
Text
id pubmed-6872489
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Endocrine Society
record_format MEDLINE/PubMed
spelling pubmed-68724892019-11-27 Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism Law, James M Morris, David E Astle, Valerie Finn, Ellie Muros, José Joaquín Robinson, Lindsay J Randell, Tabitha Denvir, Louise Symonds, Michael E Budge, Helen J Endocr Soc Clinical Research Articles OBJECTIVE: The interaction between thyroid status and brown adipose tissue (BAT) activation is complex. We assessed the effect of autoimmune hypothyroidism (ATD) in female children on BAT activation, measured using infrared thermography. DESIGN: Twenty-six female participants (14 with ATD and 12 healthy controls) between 5 and 17 years of age attended a single study session. Thermal images were taken of the supraclavicular region before, and after, the introduction of a cool stimulus. RESULTS: Participants with ATD had lower resting (hypothyroid, 34.9 ± 0.7°C; control, 35.4 ± 0.5°C; P = 0.03) and stimulated (hypothyroid, 35.0 ± 0.6°C; control, 35.5 ± 0.5°C; P = 0.04) supraclavicular temperatures compared with controls, but there was no difference between groups in the temperature increase with stimulation. BAT activation, calculated as the relative temperature change comparing the supraclavicular temperature to a sternal reference region, was reduced in participants with ATD (hypothyroid, 0.1 ± 0.1°C; control, 0.2 ± 0.2°C; P = 0.04). Children with ATD were frequently biochemically euthyroid due to replacement therapy, but, despite this, increased relative supraclavicular temperature was closely associated with increased TSH (r = 0.7, P = 0.01) concentrations. CONCLUSIONS: Girls with ATD had an attenuated thermogenic response to cold stimulation compared with healthy controls, but, contrary to expectation, those with suboptimal biochemical control (with higher TSH) showed increased BAT activation. This suggests that the underlying disease process may have a negative effect on BAT response, but high levels of TSH can mitigate, and even stimulate, BAT activity. In summary, thyroid status is a complex determinant of BAT activity in girls with ATD. Endocrine Society 2019-10-11 /pmc/articles/PMC6872489/ /pubmed/31777769 http://dx.doi.org/10.1210/js.2019-00342 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research Articles
Law, James M
Morris, David E
Astle, Valerie
Finn, Ellie
Muros, José Joaquín
Robinson, Lindsay J
Randell, Tabitha
Denvir, Louise
Symonds, Michael E
Budge, Helen
Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
title Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
title_full Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
title_fullStr Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
title_full_unstemmed Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
title_short Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism
title_sort brown adipose tissue response to cold stimulation is reduced in girls with autoimmune hypothyroidism
topic Clinical Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872489/
https://www.ncbi.nlm.nih.gov/pubmed/31777769
http://dx.doi.org/10.1210/js.2019-00342
work_keys_str_mv AT lawjamesm brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT morrisdavide brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT astlevalerie brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT finnellie brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT murosjosejoaquin brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT robinsonlindsayj brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT randelltabitha brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT denvirlouise brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT symondsmichaele brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism
AT budgehelen brownadiposetissueresponsetocoldstimulationisreducedingirlswithautoimmunehypothyroidism