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Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGF-β from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer

Screening of several TNBC cell lines showed altered Smad2 and Smad3 protein levels compared to normal mammary epithelial cells, suggesting the possibility that it could play an important role in the escape of cancer cells from TGF-β mediated growth inhibition. To assess the functional relevance of t...

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Detalles Bibliográficos
Autores principales:	Singha, Prajjal K., Pandeswara, Srilakshmi, Geng, Hui, Lan, Rongpei, Venkatachalam, Manjeri A., Dobi, Albert, Srivastava, Shiv, Saikumar, Pothana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872668/ https://www.ncbi.nlm.nih.gov/pubmed/31798766 http://dx.doi.org/10.18632/genesandcancer.194

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