New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

ABSTRACT: Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures we...

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Detalles Bibliográficos
Autores principales: Li, Xiang-Mei, Jiang, Xian-Jun, Wei, Guo-Zhu, Ren, Li-Hua, Wang, Li-Xia, Cheng, Xue-Lian, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872691/
https://www.ncbi.nlm.nih.gov/pubmed/31724098
http://dx.doi.org/10.1007/s13659-019-00226-z
Descripción
Sumario:ABSTRACT: Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-00226-z) contains supplementary material, which is available to authorized users.

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