New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata

ABSTRACT: Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures we...

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Autores principales: Li, Xiang-Mei, Jiang, Xian-Jun, Wei, Guo-Zhu, Ren, Li-Hua, Wang, Li-Xia, Cheng, Xue-Lian, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872691/
https://www.ncbi.nlm.nih.gov/pubmed/31724098
http://dx.doi.org/10.1007/s13659-019-00226-z
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author Li, Xiang-Mei
Jiang, Xian-Jun
Wei, Guo-Zhu
Ren, Li-Hua
Wang, Li-Xia
Cheng, Xue-Lian
Wang, Fei
author_facet Li, Xiang-Mei
Jiang, Xian-Jun
Wei, Guo-Zhu
Ren, Li-Hua
Wang, Li-Xia
Cheng, Xue-Lian
Wang, Fei
author_sort Li, Xiang-Mei
collection PubMed
description ABSTRACT: Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-00226-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-68726912019-12-06 New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata Li, Xiang-Mei Jiang, Xian-Jun Wei, Guo-Zhu Ren, Li-Hua Wang, Li-Xia Cheng, Xue-Lian Wang, Fei Nat Prod Bioprospect Short Communication ABSTRACT: Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3–10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-00226-z) contains supplementary material, which is available to authorized users. Springer Singapore 2019-11-14 /pmc/articles/PMC6872691/ /pubmed/31724098 http://dx.doi.org/10.1007/s13659-019-00226-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Li, Xiang-Mei
Jiang, Xian-Jun
Wei, Guo-Zhu
Ren, Li-Hua
Wang, Li-Xia
Cheng, Xue-Lian
Wang, Fei
New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
title New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
title_full New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
title_fullStr New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
title_full_unstemmed New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
title_short New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
title_sort new iboga-type indole alkaloids from tabernaemontana divaricata
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872691/
https://www.ncbi.nlm.nih.gov/pubmed/31724098
http://dx.doi.org/10.1007/s13659-019-00226-z
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