Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch

ABSTRACT: Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1–3, two aconitine-type diterpenoid alkaloids 4–5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Co...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Meng, Xian-Hua, Chai, Tian, Yang, Jun-Li, Shi, Yan-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872700/
https://www.ncbi.nlm.nih.gov/pubmed/31728851
http://dx.doi.org/10.1007/s13659-019-00227-y
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author Wang, Jun
Meng, Xian-Hua
Chai, Tian
Yang, Jun-Li
Shi, Yan-Ping
author_facet Wang, Jun
Meng, Xian-Hua
Chai, Tian
Yang, Jun-Li
Shi, Yan-Ping
author_sort Wang, Jun
collection PubMed
description ABSTRACT: Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1–3, two aconitine-type diterpenoid alkaloids 4–5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ(1−42) aggregates. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-00227-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-68727002019-12-06 Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch Wang, Jun Meng, Xian-Hua Chai, Tian Yang, Jun-Li Shi, Yan-Ping Nat Prod Bioprospect Original Article ABSTRACT: Diterpenoid alkaloids have neroprotective activity. Herein, three napelline-type diterpenoid alkaloids 1–3, two aconitine-type diterpenoid alkaloids 4–5, and one isoquinline-type alkaloid 6, as well as one lignan glycoside 7, have been isolated from the roots of Aconitum pendulum Busch. Compounds 1 and 7 were new compounds, and their chemical structures were determined on the basis of nuclear magnetic resonance (NMR) spectra and mass spectrometry analysis. A ThT assay revealed that compound 2 showed significant disaggregation potency on the Aβ(1−42) aggregates. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-019-00227-y) contains supplementary material, which is available to authorized users. Springer Singapore 2019-11-14 /pmc/articles/PMC6872700/ /pubmed/31728851 http://dx.doi.org/10.1007/s13659-019-00227-y Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Wang, Jun
Meng, Xian-Hua
Chai, Tian
Yang, Jun-Li
Shi, Yan-Ping
Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch
title Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch
title_full Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch
title_fullStr Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch
title_full_unstemmed Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch
title_short Diterpenoid Alkaloids and One Lignan from the Roots of Aconitum pendulum Busch
title_sort diterpenoid alkaloids and one lignan from the roots of aconitum pendulum busch
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872700/
https://www.ncbi.nlm.nih.gov/pubmed/31728851
http://dx.doi.org/10.1007/s13659-019-00227-y
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