Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

ABSTRACT: An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition t...

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Detalles Bibliográficos
Autores principales: Nalin Rathnayake, G. R., Savitri Kumar, N., Jayasinghe, Lalith, Araya, Hiroshi, Fujimoto, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872701/
https://www.ncbi.nlm.nih.gov/pubmed/31729648
http://dx.doi.org/10.1007/s13659-019-00225-0
Descripción
Sumario:ABSTRACT: An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1–5, 7 and 8 from P. microspora are reported here for the first time. GRAPHIC ABSTRACT: [Image: see text]

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