Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

ABSTRACT: An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition t...

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Detalles Bibliográficos
Autores principales: Nalin Rathnayake, G. R., Savitri Kumar, N., Jayasinghe, Lalith, Araya, Hiroshi, Fujimoto, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872701/
https://www.ncbi.nlm.nih.gov/pubmed/31729648
http://dx.doi.org/10.1007/s13659-019-00225-0
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author Nalin Rathnayake, G. R.
Savitri Kumar, N.
Jayasinghe, Lalith
Araya, Hiroshi
Fujimoto, Yoshinori
author_facet Nalin Rathnayake, G. R.
Savitri Kumar, N.
Jayasinghe, Lalith
Araya, Hiroshi
Fujimoto, Yoshinori
author_sort Nalin Rathnayake, G. R.
collection PubMed
description ABSTRACT: An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1–5, 7 and 8 from P. microspora are reported here for the first time. GRAPHIC ABSTRACT: [Image: see text]
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spelling pubmed-68727012019-12-06 Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora Nalin Rathnayake, G. R. Savitri Kumar, N. Jayasinghe, Lalith Araya, Hiroshi Fujimoto, Yoshinori Nat Prod Bioprospect Original Article ABSTRACT: An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1–5, 7 and 8 from P. microspora are reported here for the first time. GRAPHIC ABSTRACT: [Image: see text] Springer Singapore 2019-11-15 /pmc/articles/PMC6872701/ /pubmed/31729648 http://dx.doi.org/10.1007/s13659-019-00225-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Nalin Rathnayake, G. R.
Savitri Kumar, N.
Jayasinghe, Lalith
Araya, Hiroshi
Fujimoto, Yoshinori
Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
title Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
title_full Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
title_fullStr Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
title_full_unstemmed Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
title_short Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
title_sort secondary metabolites produced by an endophytic fungus pestalotiopsis microspora
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872701/
https://www.ncbi.nlm.nih.gov/pubmed/31729648
http://dx.doi.org/10.1007/s13659-019-00225-0
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