Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Leishmania RNA virus (LRV) is an important virulence factor associated with the development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated disease exacerbation relies on TLR3 activation, but downstream mechanisms remain largely unexplored. Here, we combine human and mouse...

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Detalles Bibliográficos
Autores principales: de Carvalho, Renan V. H., Lima-Junior, Djalma S., da Silva, Marcus Vinícius G., Dilucca, Marisa, Rodrigues, Tamara S., Horta, Catarina V., Silva, Alexandre L. N., da Silva, Patrick F., Frantz, Fabiani G., Lorenzon, Lucas B., Souza, Marcos Michel, Almeida, Fausto, Cantanhêde, Lilian M., Ferreira, Ricardo de Godoi M., Cruz, Angela K., Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872735/
https://www.ncbi.nlm.nih.gov/pubmed/31754185
http://dx.doi.org/10.1038/s41467-019-13356-2

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