The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation

Monocytes and macrophages contribute to pathogenesis of various inflammatory diseases, including auto-inflammatory diseases, cancer, sepsis, or atherosclerosis. They do so by production of cytokines, the central regulators of inflammation. Isoprenylation of small G-proteins is involved in regulation...

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Detalles Bibliográficos
Autores principales: Fu, Hang, Alabdullah, Mohamad, Großmann, Julia, Spieler, Florian, Abdosh, Reem, Lutz, Veronika, Kalies, Katrin, Knöpp, Kai, Rieckmann, Max, Koch, Susanne, Noutsias, Michel, Pilowski, Claudia, Dutzmann, Jochen, Sedding, Daniel, Hüttelmaier, Stefan, Umezawa, Kazuo, Werdan, Karl, Loppnow, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872739/
https://www.ncbi.nlm.nih.gov/pubmed/31754207
http://dx.doi.org/10.1038/s41419-019-2109-9

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