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Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile

Cells in simulated microgravity undergo a reversible morphology switch, causing the appearance of two distinct phenotypes. Despite the dramatic splitting into an adherent-fusiform and a floating-spherical population, when looking at the gene-expression phase space, cell transition ends up in a large...

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Detalles Bibliográficos
Autores principales: Po, Agnese, Giuliani, Alessandro, Masiello, Maria Grazia, Cucina, Alessandra, Catizone, Angela, Ricci, Giulia, Chiacchiarini, Martina, Tafani, Marco, Ferretti, Elisabetta, Bizzarri, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872750/
https://www.ncbi.nlm.nih.gov/pubmed/31799378
http://dx.doi.org/10.1038/s41526-019-0088-x