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Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()

INTRODUCTION: It is acknowledged that any claim of efficacy of allergen immunotherapy must be done for each specific product, and this remains true also for venom immunotherapy (VIT). Thus, we evaluated the efficacy and safety of a specific tyrosine-adsorbed VIT for vespula spp. and honeybee in real...

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Autores principales: Severino, Maurizio, Simioni, Livio, Bonadonna, Patrizia, Cantone, Renato, Cortellini, Gabriele, Crescioli, Stefano, D'Angelo, Anna, La Rosa, Luigi, Macchia, Donatella, Martignago, Irene, Massolo, Alessandro, Reccardini, Federico, Bagnasco, Diego, Passalacqua, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872772/
https://www.ncbi.nlm.nih.gov/pubmed/31768218
http://dx.doi.org/10.1016/j.waojou.2019.100086
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author Severino, Maurizio
Simioni, Livio
Bonadonna, Patrizia
Cantone, Renato
Cortellini, Gabriele
Crescioli, Stefano
D'Angelo, Anna
La Rosa, Luigi
Macchia, Donatella
Martignago, Irene
Massolo, Alessandro
Reccardini, Federico
Bagnasco, Diego
Passalacqua, Giovanni
author_facet Severino, Maurizio
Simioni, Livio
Bonadonna, Patrizia
Cantone, Renato
Cortellini, Gabriele
Crescioli, Stefano
D'Angelo, Anna
La Rosa, Luigi
Macchia, Donatella
Martignago, Irene
Massolo, Alessandro
Reccardini, Federico
Bagnasco, Diego
Passalacqua, Giovanni
author_sort Severino, Maurizio
collection PubMed
description INTRODUCTION: It is acknowledged that any claim of efficacy of allergen immunotherapy must be done for each specific product, and this remains true also for venom immunotherapy (VIT). Thus, we evaluated the efficacy and safety of a specific tyrosine-adsorbed VIT for vespula spp. and honeybee in real-life. METHODS: Consecutive patients diagnosed with hymenoptera allergy, and receiving VIT for either vespula or honeybee with a tyrosine-adsorbed preparation were observed to evaluate the grade of reaction (according to Muller) at the first field re-sting. A modified ultra-rush protocol was used. RESULTS: A total of 247 patients (73 female) were observed (102 honeybee, group H, 145 vespula, group V). Seventy-five patients in group H had a re-sting, and 74/75 had a lower grade reaction at re-sting as compared to the pre-VIT reaction. Considering systemic reactions, protection was achieved in 89% of patients. In group V 118 patients were re-stung, and 76/118 patients with previous grade III-IV reaction had no more systemic reaction under VIT. Overall, considering systemic reactions, protection was achieved in 92% of subjects. Of note, in both groups there was a clear inverse correlation between the severity of pre-VIT and during VIT reactions. The duration of VIT at the time of re-sting did not affect the efficacy. The safety was overall good, with 18% ad 15.4% local reactions in groups H and V, respectively. DISCUSSION: Modified extracts, including tyrosine-absorbed, have the aim of improving the safety of VIT still yet maintaining the efficacy. Field re-sting is the best way to assess the efficacy in real life. In this observational study we could confirm the protective efficacy of the tyrosine-adsorbed extract, with a good safety expecially in the build-up using a modified-rush protocol. CONCLUSION: The tyrosine-adsorbed VIT used herein is a viable and advantageous form of treatment for hymenoptera allergy.
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spelling pubmed-68727722019-11-25 Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy() Severino, Maurizio Simioni, Livio Bonadonna, Patrizia Cantone, Renato Cortellini, Gabriele Crescioli, Stefano D'Angelo, Anna La Rosa, Luigi Macchia, Donatella Martignago, Irene Massolo, Alessandro Reccardini, Federico Bagnasco, Diego Passalacqua, Giovanni World Allergy Organ J Article INTRODUCTION: It is acknowledged that any claim of efficacy of allergen immunotherapy must be done for each specific product, and this remains true also for venom immunotherapy (VIT). Thus, we evaluated the efficacy and safety of a specific tyrosine-adsorbed VIT for vespula spp. and honeybee in real-life. METHODS: Consecutive patients diagnosed with hymenoptera allergy, and receiving VIT for either vespula or honeybee with a tyrosine-adsorbed preparation were observed to evaluate the grade of reaction (according to Muller) at the first field re-sting. A modified ultra-rush protocol was used. RESULTS: A total of 247 patients (73 female) were observed (102 honeybee, group H, 145 vespula, group V). Seventy-five patients in group H had a re-sting, and 74/75 had a lower grade reaction at re-sting as compared to the pre-VIT reaction. Considering systemic reactions, protection was achieved in 89% of patients. In group V 118 patients were re-stung, and 76/118 patients with previous grade III-IV reaction had no more systemic reaction under VIT. Overall, considering systemic reactions, protection was achieved in 92% of subjects. Of note, in both groups there was a clear inverse correlation between the severity of pre-VIT and during VIT reactions. The duration of VIT at the time of re-sting did not affect the efficacy. The safety was overall good, with 18% ad 15.4% local reactions in groups H and V, respectively. DISCUSSION: Modified extracts, including tyrosine-absorbed, have the aim of improving the safety of VIT still yet maintaining the efficacy. Field re-sting is the best way to assess the efficacy in real life. In this observational study we could confirm the protective efficacy of the tyrosine-adsorbed extract, with a good safety expecially in the build-up using a modified-rush protocol. CONCLUSION: The tyrosine-adsorbed VIT used herein is a viable and advantageous form of treatment for hymenoptera allergy. World Allergy Organization 2019-11-19 /pmc/articles/PMC6872772/ /pubmed/31768218 http://dx.doi.org/10.1016/j.waojou.2019.100086 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Severino, Maurizio
Simioni, Livio
Bonadonna, Patrizia
Cantone, Renato
Cortellini, Gabriele
Crescioli, Stefano
D'Angelo, Anna
La Rosa, Luigi
Macchia, Donatella
Martignago, Irene
Massolo, Alessandro
Reccardini, Federico
Bagnasco, Diego
Passalacqua, Giovanni
Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
title Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
title_full Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
title_fullStr Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
title_full_unstemmed Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
title_short Efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
title_sort efficacy and safety of honeybee and wasp tyrosine-adsorbed venom immunotherapy()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872772/
https://www.ncbi.nlm.nih.gov/pubmed/31768218
http://dx.doi.org/10.1016/j.waojou.2019.100086
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