Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients

Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK–induced ACC phosphorylation...

Descripción completa

Detalles Bibliográficos
Autores principales: Kautbally, Shakeel, Lepropre, Sophie, Onselaer, Marie-Blanche, Le Rigoleur, Astrid, Ginion, Audrey, De Meester de Ravenstein, Christophe, Ambroise, Jerome, Boudjeltia, Karim Z., Octave, Marie, Wéra, Odile, Hego, Alexandre, Pincemail, Joël, Cheramy-Bien, Jean-Paul, Huby, Thierry, Giera, Martin, Gerber, Bernhard, Pouleur, Anne-Catherine, Guigas, Bruno, Vanoverschelde, Jean-Louis, Kefer, Joelle, Bertrand, Luc, Oury, Cécile, Horman, Sandrine, Beauloye, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872775/
https://www.ncbi.nlm.nih.gov/pubmed/31768476
http://dx.doi.org/10.1016/j.jacbts.2019.04.005
Descripción
Sumario:Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK–induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK–induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function.

Ejemplares similares