Cargando…

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients with type 2 diabetes mellitus suggest a direct effect of empagliflozin on the heart. These patients frequently have HF with pre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Juni, Rio P., Kuster, Diederik W.D., Goebel, Max, Helmes, Michiel, Musters, René J.P., van der Velden, Jolanda, Koolwijk, Pieter, Paulus, Walter J., van Hinsbergh, Victor W.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872802/ https://www.ncbi.nlm.nih.gov/pubmed/31768475 http://dx.doi.org/10.1016/j.jacbts.2019.04.003

Ejemplares similares

Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes
por: Nollet, Edgar E., et al.
Publicado: (2020)

End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium
por: Najafi, Aref, et al.
Publicado: (2019)

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes
por: Verkaik, Melissa, et al.
Publicado: (2018)

Dysregulation of cardiac endothelial lncRNA H19 in COVID19 patients induces endothelial dysfunction, which impairs cardiomyocyte function
por: Juni, Rio, et al.
Publicado: (2022)

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy
por: Bollen, Ilse A. E., et al.
Publicado: (2017)

Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output
por: Helmes, Michiel, et al.
Publicado: (2016)

Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes
por: Schuldt, Maike, et al.
Publicado: (2021)

Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes
por: Iborra-Egea, Oriol, et al.
Publicado: (2019)

Angiopoietin-2 correlates with pulmonary capillary permeability and disease severity in critically ill patients
por: van der Heijden, M, et al.
Publicado: (2007)

HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells
por: Nauta, Tessa D., et al.
Publicado: (2016)

Correction: HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells
por: Nauta, Tessa D., et al.
Publicado: (2016)

Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
por: Vučković, Sofija, et al.
Publicado: (2022)

Cardiac myosin binding protein C phosphorylation in cardiac disease
por: Kuster, Diederik W. D., et al.
Publicado: (2011)

Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis
por: Umbarkar, Prachi, et al.
Publicado: (2019)

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1
por: Pei, Jiayi, et al.
Publicado: (2019)

Carvedilol Prevents Redox Inactivation of Cardiomyocyte Β(1)-Adrenergic Receptors
por: Park, Misun, et al.
Publicado: (2018)

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity
por: Tasev, Dimitar, et al.
Publicado: (2015)

Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury
por: Hara, Hironori, et al.
Publicado: (2018)

Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes
por: Sewanan, Lorenzo R., et al.
Publicado: (2019)

Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy
por: Wang, Bin, et al.
Publicado: (2020)

Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome
por: Waddingham, Mark T., et al.
Publicado: (2023)

Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
por: Ye, Lincai, et al.
Publicado: (2020)

FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo
por: Kuhn, Christian, et al.
Publicado: (2021)

The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances
por: Attaye, Ilias, et al.
Publicado: (2017)

Hypoxic Signaling During Tissue Repair and Regenerative Medicine
por: Nauta, Tessa D., et al.
Publicado: (2014)

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro
por: Nauta, Tessa D., et al.
Publicado: (2016)

Translational Insights in Coronary Microvascular Disease
por: Gurunathan, Sharavana, et al.
Publicado: (2023)

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate
por: Kolwicz, Stephen C., et al.
Publicado: (2019)

Abstract 23 HLA-Homozygous iPSC from Cord Blood for the Generation of Cardiomyocytes for Allogeneic Cell Therapy to the Heart
por: Becker, Fabienne, et al.
Publicado: (2023)

Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart
por: Bollen, Ilse A. E., et al.
Publicado: (2015)

Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential
por: Tasev, Dimitar, et al.
Publicado: (2018)

Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles
por: Goette, Andreas, et al.
Publicado: (2009)

Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression
por: Plaisance, Isabelle, et al.
Publicado: (2016)

CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs)
por: Tasev, Dimitar, et al.
Publicado: (2016)

In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves
por: Uiterwijk, Marcelle, et al.
Publicado: (2020)

Equivalence of MammaPrint array types in clinical trials and diagnostics
por: Beumer, Inès, et al.
Publicado: (2016)

Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes
por: Faber, Jaeike W., et al.
Publicado: (2022)

Unraveling the Genotype‐Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity‐Related Cardiac Defects as a Major Disease Modifier
por: Nollet, Edgar E., et al.
Publicado: (2020)

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a
por: Lei, Zhiyong, et al.
Publicado: (2021)

In vitro model to study the effects of matrix stiffening on Ca(2+) handling and myofilament function in isolated adult rat cardiomyocytes
por: van Deel, Elza D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5frip56ncksjr1vbt5u66jscj7