Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediatin...

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Detalles Bibliográficos
Autores principales: Ikeda, Shohei, Mukai, Risa, Mizushima, Wataru, Zhai, Peiyong, Oka, Shin-ichi, Nakamura, Michinari, Del Re, Dominic P., Sciarretta, Sebastiano, Hsu, Chiao-Po, Shimokawa, Hiroaki, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872826/
https://www.ncbi.nlm.nih.gov/pubmed/31768477
http://dx.doi.org/10.1016/j.jacbts.2019.05.006
Descripción
Sumario:Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.

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