Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediatin...

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Autores principales: Ikeda, Shohei, Mukai, Risa, Mizushima, Wataru, Zhai, Peiyong, Oka, Shin-ichi, Nakamura, Michinari, Del Re, Dominic P., Sciarretta, Sebastiano, Hsu, Chiao-Po, Shimokawa, Hiroaki, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872826/
https://www.ncbi.nlm.nih.gov/pubmed/31768477
http://dx.doi.org/10.1016/j.jacbts.2019.05.006
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author Ikeda, Shohei
Mukai, Risa
Mizushima, Wataru
Zhai, Peiyong
Oka, Shin-ichi
Nakamura, Michinari
Del Re, Dominic P.
Sciarretta, Sebastiano
Hsu, Chiao-Po
Shimokawa, Hiroaki
Sadoshima, Junichi
author_facet Ikeda, Shohei
Mukai, Risa
Mizushima, Wataru
Zhai, Peiyong
Oka, Shin-ichi
Nakamura, Michinari
Del Re, Dominic P.
Sciarretta, Sebastiano
Hsu, Chiao-Po
Shimokawa, Hiroaki
Sadoshima, Junichi
author_sort Ikeda, Shohei
collection PubMed
description Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure.
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spelling pubmed-68728262019-11-25 Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart Ikeda, Shohei Mukai, Risa Mizushima, Wataru Zhai, Peiyong Oka, Shin-ichi Nakamura, Michinari Del Re, Dominic P. Sciarretta, Sebastiano Hsu, Chiao-Po Shimokawa, Hiroaki Sadoshima, Junichi JACC Basic Transl Sci PRECLINICAL RESEARCH Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure. Elsevier 2019-09-23 /pmc/articles/PMC6872826/ /pubmed/31768477 http://dx.doi.org/10.1016/j.jacbts.2019.05.006 Text en © 2019 Published by Elsevier on behalf of the American College of Cardiology Foundation. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Ikeda, Shohei
Mukai, Risa
Mizushima, Wataru
Zhai, Peiyong
Oka, Shin-ichi
Nakamura, Michinari
Del Re, Dominic P.
Sciarretta, Sebastiano
Hsu, Chiao-Po
Shimokawa, Hiroaki
Sadoshima, Junichi
Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
title Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
title_full Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
title_fullStr Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
title_full_unstemmed Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
title_short Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
title_sort yes-associated protein (yap) facilitates pressure overload–induced dysfunction in the diabetic heart
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872826/
https://www.ncbi.nlm.nih.gov/pubmed/31768477
http://dx.doi.org/10.1016/j.jacbts.2019.05.006
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