Cargando…

Synthesis, antibacterial activity and molecular docking study of vanillin derived 1,4-disubstituted 1,2,3-triazoles as inhibitors of bacterial DNA synthesis

Antimicrobial resistance (AMR) compelled scientists in general while pharmacists, chemists and biologists in specific to believe that we could always remain ahead of the pathogens. The pipeline of new drugs is running gasping and the inducements to develop new antimicrobials to address the global pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hussain, Mumtaz, Qadri, Tahir, Hussain, Zahid, Saeed, Aamer, Channar, Pervaiz Ali, Shehzadi, Syeda Aaliya, Hassan, Mubashir, Larik, Fayaz Ali, Mahmood, Tarique, Malik, Arif
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872831/ https://www.ncbi.nlm.nih.gov/pubmed/31768438 http://dx.doi.org/10.1016/j.heliyon.2019.e02812

Ejemplares similares

Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking
por: Channar, Pervaiz Ali, et al.
Publicado: (2017)

Identification of two novel thiazolidin-2-imines as tyrosinase inhibitors: synthesis, crystal structure, molecular docking and DFT studies
por: Shehzadi, Syeda Aaliya, et al.
Publicado: (2022)

Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation
por: Ujan, Rabail, et al.
Publicado: (2019)

Synthesis, biological evaluation and in silico investigations of benzotriazole derivatives as potential inhibitors of NIMA related kinase
por: Qadri, Tahir, et al.
Publicado: (2023)

Bis-Schiff bases of 2,2′-dibromobenzidine as efficient corrosion inhibitors for mild steel in acidic medium
por: Arshad, Ifzan, et al.
Publicado: (2020)

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics
por: Shahzad, Danish, et al.
Publicado: (2019)

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors
por: Hassan, Sidra, et al.
Publicado: (2018)

Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
por: Beyki, Khalil, et al.
Publicado: (2016)

Novel adamantyl clubbed iminothiazolidinones as promising elastase inhibitors: design, synthesis, molecular docking, ADMET and DFT studies
por: Ahmed, Atteeque, et al.
Publicado: (2022)

Analysis of 1-Aroyl-3-[3-chloro-2-methylphenyl] Thiourea Hybrids as Potent Urease Inhibitors: Synthesis, Biochemical Evaluation and Computational Approach
por: Rasheed, Samina, et al.
Publicado: (2022)

Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitors
por: Mustafa, Muhammad Naeem, et al.
Publicado: (2023)

Synthesis of Chiral 1,4-Disubstituted-1,2,3-Triazole Derivatives from Amino Acids
por: Klein, Michael, et al.
Publicado: (2009)

Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors
por: Channar, Pervaiz Ali, et al.
Publicado: (2022)

Design, Synthesis, Kinetic Analysis and Pharmacophore-Directed Discovery of 3-Ethylaniline Hybrid Imino-Thiazolidinone as Potential Inhibitor of Carbonic Anhydrase II: An Emerging Biological Target for Treatment of Cancer
por: Ahmed, Atteeque, et al.
Publicado: (2022)

Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase
por: Saeed, Aamer, et al.
Publicado: (2023)

Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona—Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers
por: Jernei, Tamás, et al.
Publicado: (2019)

Regioselective Synthesis and Molecular Docking Studies of 1,5-Disubstituted 1,2,3-Triazole Derivatives of Pyrimidine Nucleobases
por: Algieri, Vincenzo, et al.
Publicado: (2022)

Synthesis of a novel resorcin[4]arene–glucose conjugate and its catalysis of the CuAAC reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles in water
por: Husain, Ali A., et al.
Publicado: (2019)

A Green Ultrasound Synthesis, Characterization and Antibacterial Evaluation of 1,4-Disubstituted 1,2,3-Triazoles Tethering Bioactive Benzothiazole Nucleus
por: Rezki, Nadjet
Publicado: (2016)

Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs
por: Abuduaini, Tuniyazi, et al.
Publicado: (2021)

Synthesis of N-perfluoroalkyl-3,4-disubstituted pyrroles by rhodium-catalyzed transannulation of N-fluoroalkyl-1,2,3-triazoles with terminal alkynes
por: Bakhanovich, Olga, et al.
Publicado: (2021)

Natural phosphate-supported Cu(ii), an efficient and recyclable catalyst for the synthesis of xanthene and 1,4-disubstituted-1,2,3-triazole derivatives
por: Amini, Abbas, et al.
Publicado: (2018)

Synthesis of 2,6-disubstituted tetrahydroazulene derivatives
por: Hussain, Zakir, et al.
Publicado: (2012)

Synthesis, DFT and molecular docking of novel (Z)-4-bromo-N-(4-butyl-3 (quinolin-3-yl)thiazol-2(3H)-ylidene)benzamide as elastase inhibitor
por: Mustafa, Muhammad Naeem, et al.
Publicado: (2023)

Highly productive and scalable approach to synthesize ticlopidine: A potent thienopyridine anti-platelet aggregation drug
por: Faisal, Muhammad, et al.
Publicado: (2020)

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes
por: Israr, Muhammad, et al.
Publicado: (2018)

Copper-catalyzed in situ oxidative-coupling for one-pot synthesis of 5-aryl-1,4-disubstituted 1,2,3-triazoles under mild conditions
por: Wang, Chao, et al.
Publicado: (2021)

Synthesis of Dense 1,2,3-Triazole Oligomers Consisting Preferentially of 1,5-Disubstituted Units via Ruthenium(II)-Catalyzed Azide–Alkyne Cycloaddition
por: Taguchi, Ryoichi, et al.
Publicado: (2023)

A practical flow synthesis of 1,2,3-triazoles
por: Drelinkiewicz, Dawid, et al.
Publicado: (2022)

Facile synthesis, crystal structure, biological evaluation, and molecular modeling studies of N-((4-acetyl phenyl) carbamothioyl) pivalamide as the multitarget-directed ligand
por: Saeed, Aamer, et al.
Publicado: (2022)

Synthesis, Structural Investigations, DNA/BSA Interactions, Molecular Docking Studies, and Anticancer Activity of a New 1,4-Disubstituted 1,2,3-Triazole Derivative
por: Göktürk, Tolga, et al.
Publicado: (2023)

Appraisal of novel azomethine–thioxoimidazolidinone conjugates as ecto-5′-nucleotidase inhibitors: synthesis and molecular docking studies
por: Channar, Pervaiz Ali, et al.
Publicado: (2022)

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles
por: Shiri, Pezhman, et al.
Publicado: (2021)

Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity
por: Pokhodylo, Nazariy, et al.
Publicado: (2013)

Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates
por: Oramas-Royo, Sandra, et al.
Publicado: (2019)

Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities
por: Hasanpour, Zahra, et al.
Publicado: (2021)

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity
por: Rečnik, Lisa-Maria, et al.
Publicado: (2020)

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2019)

Designing Click One-Pot Synthesis and Antidiabetic Studies of 1,2,3-Triazole Derivatives
por: Shafique, Kainat, et al.
Publicado: (2023)

A One-Pot Six-Component Reaction for the Synthesis of 1,5-Disubstituted Tetrazol-1,2,3-Triazole Hybrids and Their Cytotoxic Activity against the MCF-7 Cell Line
por: Aguilar-Morales, Cesia M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tuk5ab7cbj0b51fgvv0umnjice