Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis

Myelofibrosis (MF) can occur due to a wide variety of causes including malignant lymphoma. We report a case of splenic marginal zone lymphoma complicated by MF mimicking primary myelofibrosis (PMF). The JAK2, CALR and MPL mutations are detected in more than 90% of PMF cases, and when detected, the d...

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Autores principales: Tsutsui, Miyuki, Yasuda, Hajime, Ota, Yasunori, Komatsu, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873034/
https://www.ncbi.nlm.nih.gov/pubmed/31762757
http://dx.doi.org/10.1159/000504129
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author Tsutsui, Miyuki
Yasuda, Hajime
Ota, Yasunori
Komatsu, Norio
author_facet Tsutsui, Miyuki
Yasuda, Hajime
Ota, Yasunori
Komatsu, Norio
author_sort Tsutsui, Miyuki
collection PubMed
description Myelofibrosis (MF) can occur due to a wide variety of causes including malignant lymphoma. We report a case of splenic marginal zone lymphoma complicated by MF mimicking primary myelofibrosis (PMF). The JAK2, CALR and MPL mutations are detected in more than 90% of PMF cases, and when detected, the diagnosis of PMF is usually straight forward. Mutational analysis should be done in all cases of MF, and in triple-negative cases, an exhaustive investigation of other causes of MF should be carried out before a diagnosis of triple-negative PMF is rendered.
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spelling pubmed-68730342019-11-22 Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis Tsutsui, Miyuki Yasuda, Hajime Ota, Yasunori Komatsu, Norio Case Rep Oncol Case Report Myelofibrosis (MF) can occur due to a wide variety of causes including malignant lymphoma. We report a case of splenic marginal zone lymphoma complicated by MF mimicking primary myelofibrosis (PMF). The JAK2, CALR and MPL mutations are detected in more than 90% of PMF cases, and when detected, the diagnosis of PMF is usually straight forward. Mutational analysis should be done in all cases of MF, and in triple-negative cases, an exhaustive investigation of other causes of MF should be carried out before a diagnosis of triple-negative PMF is rendered. S. Karger AG 2019-11-01 /pmc/articles/PMC6873034/ /pubmed/31762757 http://dx.doi.org/10.1159/000504129 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Tsutsui, Miyuki
Yasuda, Hajime
Ota, Yasunori
Komatsu, Norio
Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis
title Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis
title_full Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis
title_fullStr Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis
title_full_unstemmed Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis
title_short Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis
title_sort splenic marginal zone lymphoma with prominent myelofibrosis mimicking triple-negative primary myelofibrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873034/
https://www.ncbi.nlm.nih.gov/pubmed/31762757
http://dx.doi.org/10.1159/000504129
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AT otayasunori splenicmarginalzonelymphomawithprominentmyelofibrosismimickingtriplenegativeprimarymyelofibrosis
AT komatsunorio splenicmarginalzonelymphomawithprominentmyelofibrosismimickingtriplenegativeprimarymyelofibrosis

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