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Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation
We report our findings in 3 cases of Creutzfeldt-Jakob disease (CJD) with visual disturbances as the initial manifestations. These cases were found to have the Heidenhain variant of CJD. Two cases initially presented with progressively blurred vision and homonymous hemianopia. The other case initial...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873069/ https://www.ncbi.nlm.nih.gov/pubmed/31762767 http://dx.doi.org/10.1159/000503274 |
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author | Sakuma, Toshiro Watanabe, Satoshi Ouchi, Ayumi Sakanishi, Yoshihito Mizota, Atsushi Ebihara, Nobuyuki |
author_facet | Sakuma, Toshiro Watanabe, Satoshi Ouchi, Ayumi Sakanishi, Yoshihito Mizota, Atsushi Ebihara, Nobuyuki |
author_sort | Sakuma, Toshiro |
collection | PubMed |
description | We report our findings in 3 cases of Creutzfeldt-Jakob disease (CJD) with visual disturbances as the initial manifestations. These cases were found to have the Heidenhain variant of CJD. Two cases initially presented with progressively blurred vision and homonymous hemianopia. The other case initially presented with blurred vision and a decrease in the central sensitivity in both eyes. These 3 cases developed neurological symptoms about 4 weeks after the onset of visual symptoms. All were diagnosed with the Heidenhain variant of CJD based on the clinical course and confirmed by positive assays of the cerebrospinal fluid for the 14-3-3 protein and tau protein. In addition, the diagnosis was confirmed by the findings of diffusion-weighted magnetic resonance imaging and electroencephalography. Patients can present with isolated visual symptoms which precede a decline in cognition by weeks due to the predominantly occipital lobe disease. The 3 patients were referred to the neurology department within 1 month of onset. The early diagnosis was necessary to avoid spread of the infection. In cases of suspected CJD, it is important to consult a neurologist quickly to make a definitive diagnosis of CJD. Ophthalmologists should be aware that visual impairments may be the first indication of CJD. |
format | Online Article Text |
id | pubmed-6873069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-68730692019-11-22 Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation Sakuma, Toshiro Watanabe, Satoshi Ouchi, Ayumi Sakanishi, Yoshihito Mizota, Atsushi Ebihara, Nobuyuki Case Rep Ophthalmol Case Report We report our findings in 3 cases of Creutzfeldt-Jakob disease (CJD) with visual disturbances as the initial manifestations. These cases were found to have the Heidenhain variant of CJD. Two cases initially presented with progressively blurred vision and homonymous hemianopia. The other case initially presented with blurred vision and a decrease in the central sensitivity in both eyes. These 3 cases developed neurological symptoms about 4 weeks after the onset of visual symptoms. All were diagnosed with the Heidenhain variant of CJD based on the clinical course and confirmed by positive assays of the cerebrospinal fluid for the 14-3-3 protein and tau protein. In addition, the diagnosis was confirmed by the findings of diffusion-weighted magnetic resonance imaging and electroencephalography. Patients can present with isolated visual symptoms which precede a decline in cognition by weeks due to the predominantly occipital lobe disease. The 3 patients were referred to the neurology department within 1 month of onset. The early diagnosis was necessary to avoid spread of the infection. In cases of suspected CJD, it is important to consult a neurologist quickly to make a definitive diagnosis of CJD. Ophthalmologists should be aware that visual impairments may be the first indication of CJD. S. Karger AG 2019-10-23 /pmc/articles/PMC6873069/ /pubmed/31762767 http://dx.doi.org/10.1159/000503274 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Sakuma, Toshiro Watanabe, Satoshi Ouchi, Ayumi Sakanishi, Yoshihito Mizota, Atsushi Ebihara, Nobuyuki Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation |
title | Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation |
title_full | Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation |
title_fullStr | Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation |
title_full_unstemmed | Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation |
title_short | Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation |
title_sort | three cases of creutzfeldt-jakob disease with visual disturbances as initial manifestation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873069/ https://www.ncbi.nlm.nih.gov/pubmed/31762767 http://dx.doi.org/10.1159/000503274 |
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