Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

Information on how insulin and insulin-like growth factors 1 and 2 (IGF-1 and -2) activate insulin receptors (IR-A and -B) and the IGF-1 receptor (IGF-1R) is crucial for understanding the difference in the biological activities of these peptide hormones. Cryo-EM studies have revealed that insulin us...

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Detalles Bibliográficos
Autores principales: Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873181/
https://www.ncbi.nlm.nih.gov/pubmed/31558604
http://dx.doi.org/10.1074/jbc.RA119.010072

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